3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl) acrylate

Base Information

Chemical Name:3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl) acrylate
CAS No.:96568-06-8
Molecular Formula:C₁₄H₁₃Cl₂FN₂O₃
Molecular Weight:347.173
Hs Code.:

Synonyms:3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl) acrylate

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Chemical Property of 3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl) acrylate

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Technology Process of 3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl) acrylate

There total 1 articles about 3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl) acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 96568-06-8
3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl) acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: PCl₅ / 0.13 h / 100 °C

2: 2.) p-TsOH*H₂O / 1.) ether, RT, 2 h, 2.) H₂O, reflux, 2.5 h

3: Ac₂O / 15 h / 130 °C

4: ethanol / 1 h / Ambient temperature

With phosphorus pentachloride; acetic anhydride; toluene-4-sulfonic acid; In ethanol;
DOI:10.1021/jm00081a013

Reference yield:

: 96568-06-8
3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl) acrylate

: 100361-18-0
7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / dioxane

2: 20percent aq. HCl / Heating

With potassium carbonate; In 1,4-dioxane;
DOI:10.1021/jm010057b

Reference yield:

: 96568-06-8
3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl) acrylate

: 99735-41-8
ciprofloxacin

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / dioxane / 0.25 h / 60 °C / or K₂CO₃ in acetonitrile, reflux, 6 h; or tetrabutylammonium fluoride in THF, 1 h

2: acetonitrile / 0.5 h / Heating

3: 1 N aq. NaOH / H₂O / 0.5 h / Heating

With sodium hydroxide; sodium hydride; In 1,4-dioxane; water; acetonitrile;
DOI:10.1021/jm00123a005