2-((3R,5S)-1-(benzyloxycarbonyl)-5-(methoxycarbonyl)-pyrrolidin-3-yl)acetic acid

Base Information

Chemical Name:2-((3R,5S)-1-(benzyloxycarbonyl)-5-(methoxycarbonyl)-pyrrolidin-3-yl)acetic acid
CAS No.:168034-49-9
Molecular Formula:C₁₆H₁₉NO₆
Molecular Weight:321.33
Hs Code.:

Synonyms:2-((3R,5S)-1-(benzyloxycarbonyl)-5-(methoxycarbonyl)-pyrrolidin-3-yl)acetic acid

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Chemical Property of 2-((3R,5S)-1-(benzyloxycarbonyl)-5-(methoxycarbonyl)-pyrrolidin-3-yl)acetic acid

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Technology Process of 2-((3R,5S)-1-(benzyloxycarbonyl)-5-(methoxycarbonyl)-pyrrolidin-3-yl)acetic acid

There total 2 articles about 2-((3R,5S)-1-(benzyloxycarbonyl)-5-(methoxycarbonyl)-pyrrolidin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117653-38-0
C₈H₁₃NO₄

: 501-53-1,94274-21-2
benzyl chloroformate

: 168034-49-9
2-((3R,5S)-1-(benzyloxycarbonyl)-5-(methoxycarbonyl)-pyrrolidin-3-yl)acetic acid

Guidance literature:: With tris[2-phenylpyridinato-C₂,N]iridium(III); In tetrahydrofuran; at 20 ℃; Inert atmosphere; Molecular sieve; Schlenk technique;
DOI:10.1021/acs.orglett.0c02207

Reference yield:

: 1-tert-butyl 2-methyl (2S)-4-(2-tert-butoxy-2-oxoethyl)-pyrrolidine-1,2-dicarboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 168034-50-2
2-((3S,5S)-1-(benzyloxycarbonyl)-5-(methoxycarbonyl)-pyrrolidin-3-yl)acetic acid

: 168034-49-9
2-((3R,5S)-1-(benzyloxycarbonyl)-5-(methoxycarbonyl)-pyrrolidin-3-yl)acetic acid

Guidance literature:: 1-tert-butyl 2-methyl (2S)-4-(2-tert-butoxy-2-oxoethyl)-pyrrolidine-1,2-dicarboxylate; With trifluoroacetic acid; In dichloromethane; for 1.5h;

benzyl chloroformate; With potassium carbonate; In water; at 0 - 20 ℃;
DOI:10.1016/j.tetasy.2009.05.003

Reference yield: 90.0%

: 168034-49-9
2-((3R,5S)-1-(benzyloxycarbonyl)-5-(methoxycarbonyl)-pyrrolidin-3-yl)acetic acid

: 1186435-24-4
1-benzyl 2-methyl (2S,4R)-4-(2-hydroxyethyl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: 2-((3R,5S)-1-(benzyloxycarbonyl)-5-(methoxycarbonyl)-pyrrolidin-3-yl)acetic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 0.333333h;
DOI:10.1111/cbdd.13743