4-fluoro-N-methyl-N-(6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-8-yl)-benzenesulfonamide

Base Information

• Chemical Name: 4-fluoro-N-methyl-N-(6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-8-yl)-benzenesulfonamide
• CAS No.: 1224930-09-9
• Molecular Formula: C₁₈H₁₈FN₃O₂S
• Molecular Weight: 359.424

Synonyms:4-fluoro-N-methyl-N-(6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-8-yl)-benzenesulfonamide

Chemical Property of 4-fluoro-N-methyl-N-(6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-8-yl)-benzenesulfonamide

Chemical Property:

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Technology Process of 4-fluoro-N-methyl-N-(6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-8-yl)-benzenesulfonamide

There total 2 articles about 4-fluoro-N-methyl-N-(6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-8-yl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-2-bromopyridine (39856-58-1) + N-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-fluoro-N-methyl-benzenesulfonamide (1187081-22-6) → 4-fluoro-N-methyl-N-(6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-8-yl)-benzenesulfonamide (1224930-09-9)

Guidance literature:

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 160 ℃; for 1h; Microwave irradiation;

Reference yield:

2-chloro-3-aminopyridine (6298-19-7) + N-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-fluoro-N-methyl-benzenesulfonamide (1187081-22-6) → 4-fluoro-N-methyl-N-(6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-8-yl)-benzenesulfonamide (1224930-09-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridinium p-toluenesulfonate; In pyridine; at 180 ℃;

DOI:10.1016/j.bmcl.2009.06.085

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) + 4-fluoro-N-methyl-N-(6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-8-yl)-benzenesulfonamide (1224930-09-9) → {8-[(4-fluoro-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-pyrido[3,2-b]indol-5-yl}-acetic acid tert-butyl ester (1224930-06-6)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/j.bmcl.2009.06.085

upstream raw materials:

2-chloro-3-aminopyridine

N-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-fluoro-N-methyl-benzenesulfonamide

3-amino-2-bromopyridine

Downstream raw materials:

{8-[(4-fluoro-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-pyrido[3,2-b]indol-5-yl}-acetic acid tert-butyl ester

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