2-(4-tert-butoxycarbonylamino-phenyl)-4-(3,4-dimethoxy-5-methoxymethoxy-phenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester

Base Information

Chemical Name:2-(4-tert-butoxycarbonylamino-phenyl)-4-(3,4-dimethoxy-5-methoxymethoxy-phenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester
CAS No.:1026587-91-6
Molecular Formula:C₃₈H₃₉N₃O₁₀
Molecular Weight:697.742
Hs Code.:

2-(4-<i>tert</i>-butoxycarbonylamino-phenyl)-4-(3,4-dimethoxy-5-methoxymethoxy-phenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester

Synonyms:2-(4-tert-butoxycarbonylamino-phenyl)-4-(3,4-dimethoxy-5-methoxymethoxy-phenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester

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Chemical Property of 2-(4-tert-butoxycarbonylamino-phenyl)-4-(3,4-dimethoxy-5-methoxymethoxy-phenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester

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Technology Process of 2-(4-tert-butoxycarbonylamino-phenyl)-4-(3,4-dimethoxy-5-methoxymethoxy-phenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester

There total 10 articles about 2-(4-tert-butoxycarbonylamino-phenyl)-4-(3,4-dimethoxy-5-methoxymethoxy-phenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81418-49-7
5-(benzyloxy)-2-bromobenzaldehyde dimethylacetal

: 1026587-91-6
2-(4-tert-butoxycarbonylamino-phenyl)-4-(3,4-dimethoxy-5-methoxymethoxy-phenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: 83 percent / tetrahydrofuran / 0.5 h / -40 °C

2.1: 65 percent / 2 N aq. HCl / tetrahydrofuran / 20 °C

3.1: resorcinol; acetate buffer; NaClO₂ / dioxane; H₂O / 20 °C / pH 3.8

4.1: K₂CO₃ / dimethylformamide / 20 °C

5.1: 4 N HCl / ethyl acetate / 20 °C

5.2: AcOH / dioxane / 4 h / Heating

6.1: i-Pr₂NEt / dimethylformamide / 20 °C

7.1: 2 N aq. NaOH; MeOH / tetrahydrofuran / 0.5 h / 20 °C

7.2: various solvent(s) / 2 h / 100 °C

8.1: K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

9.1: H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 2 h / 20 °C / 1551.49 Torr

10.1: K₂CO₃ / dimethylformamide / 50 °C

With hydrogenchloride; methanol; sodium hydroxide; sodium chlorite; n-butyllithium; acetate buffer; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; recorcinol; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h

Reference yield:

: N,N-dimethyl-4,5-dimethoxy-3-(methoxymethoxy)benzamide

: 1026587-91-6
2-(4-tert-butoxycarbonylamino-phenyl)-4-(3,4-dimethoxy-5-methoxymethoxy-phenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: 83 percent / tetrahydrofuran / 0.5 h / -40 °C

2.1: 65 percent / 2 N aq. HCl / tetrahydrofuran / 20 °C

3.1: resorcinol; acetate buffer; NaClO₂ / dioxane; H₂O / 20 °C / pH 3.8

4.1: K₂CO₃ / dimethylformamide / 20 °C

5.1: 4 N HCl / ethyl acetate / 20 °C

5.2: AcOH / dioxane / 4 h / Heating

6.1: i-Pr₂NEt / dimethylformamide / 20 °C

7.1: 2 N aq. NaOH; MeOH / tetrahydrofuran / 0.5 h / 20 °C

7.2: various solvent(s) / 2 h / 100 °C

8.1: K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

9.1: H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 2 h / 20 °C / 1551.49 Torr

10.1: K₂CO₃ / dimethylformamide / 50 °C

With hydrogenchloride; methanol; sodium hydroxide; sodium chlorite; n-butyllithium; acetate buffer; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; recorcinol; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h

Reference yield:

: 212501-71-8
2-(3,4-dimethoxy-5-methoxymethoxybenzoyl)-5-benzyloxybenzaldehyde

: 1026587-91-6
2-(4-tert-butoxycarbonylamino-phenyl)-4-(3,4-dimethoxy-5-methoxymethoxy-phenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: resorcinol; acetate buffer; NaClO₂ / dioxane; H₂O / 20 °C / pH 3.8

2.1: K₂CO₃ / dimethylformamide / 20 °C

3.1: 4 N HCl / ethyl acetate / 20 °C

3.2: AcOH / dioxane / 4 h / Heating

4.1: i-Pr₂NEt / dimethylformamide / 20 °C

5.1: 2 N aq. NaOH; MeOH / tetrahydrofuran / 0.5 h / 20 °C

5.2: various solvent(s) / 2 h / 100 °C

6.1: K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

7.1: H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 2 h / 20 °C / 1551.49 Torr

8.1: K₂CO₃ / dimethylformamide / 50 °C

With hydrogenchloride; methanol; sodium hydroxide; sodium chlorite; acetate buffer; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; recorcinol; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h