methoxymethyl 7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethoxy)benzoyl]-3-isocoumarincarboxylate

Base Information

Chemical Name:methoxymethyl 7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethoxy)benzoyl]-3-isocoumarincarboxylate
CAS No.:347423-81-8
Molecular Formula:C₂₉H₂₈O₁₀
Molecular Weight:536.535
Hs Code.:

Synonyms:methoxymethyl 7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethoxy)benzoyl]-3-isocoumarincarboxylate

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Chemical Property of methoxymethyl 7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethoxy)benzoyl]-3-isocoumarincarboxylate

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Technology Process of methoxymethyl 7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethoxy)benzoyl]-3-isocoumarincarboxylate

There total 7 articles about methoxymethyl 7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethoxy)benzoyl]-3-isocoumarincarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-30-2
chloromethyl methyl ether

: 7-benzyloxy-4-(3,4-dimethoxy-5-methoxymethoxy-phenyl)-1-oxo-1H-isochromene-3-carboxylic acid

: 347423-81-8
methoxymethyl 7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethoxy)benzoyl]-3-isocoumarincarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm000558h

Reference yield:

: 81418-49-7
5-(benzyloxy)-2-bromobenzaldehyde dimethylacetal

: 347423-81-8
methoxymethyl 7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethoxy)benzoyl]-3-isocoumarincarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: 83 percent / tetrahydrofuran / 0.5 h / -40 °C

2.1: 65 percent / 2 N aq. HCl / tetrahydrofuran / 20 °C

3.1: resorcinol; acetate buffer; NaClO₂ / dioxane; H₂O / 20 °C / pH 3.8

4.1: K₂CO₃ / dimethylformamide / 20 °C

5.1: 4 N HCl / ethyl acetate / 20 °C

5.2: AcOH / dioxane / 4 h / Heating

6.1: i-Pr₂NEt / dimethylformamide / 20 °C

With hydrogenchloride; sodium chlorite; n-butyllithium; acetate buffer; potassium carbonate; N-ethyl-N,N-diisopropylamine; recorcinol; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h

Reference yield:

: N,N-dimethyl-4,5-dimethoxy-3-(methoxymethoxy)benzamide

: 347423-81-8
methoxymethyl 7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethoxy)benzoyl]-3-isocoumarincarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: 83 percent / tetrahydrofuran / 0.5 h / -40 °C

2.1: 65 percent / 2 N aq. HCl / tetrahydrofuran / 20 °C

3.1: resorcinol; acetate buffer; NaClO₂ / dioxane; H₂O / 20 °C / pH 3.8

4.1: K₂CO₃ / dimethylformamide / 20 °C

5.1: 4 N HCl / ethyl acetate / 20 °C

5.2: AcOH / dioxane / 4 h / Heating

6.1: i-Pr₂NEt / dimethylformamide / 20 °C

With hydrogenchloride; sodium chlorite; n-butyllithium; acetate buffer; potassium carbonate; N-ethyl-N,N-diisopropylamine; recorcinol; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h