(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,2-difluoro-1,3-benzodioxol-4-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide

Base Information

• Chemical Name: (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,2-difluoro-1,3-benzodioxol-4-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide
• CAS No.: 1092476-50-0
• Molecular Formula: C₂₂H₂₀F₈N₄O₃
• Molecular Weight: 540.413
• Mol file: 1092476-50-0.mol

Synonyms:(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,2-difluoro-1,3-benzodioxol-4-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide

Chemical Property of (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,2-difluoro-1,3-benzodioxol-4-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,2-difluoro-1,3-benzodioxol-4-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide

There total 3 articles about (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,2-difluoro-1,3-benzodioxol-4-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3,5-bis(trifluoromethyl)phenylhydrazine (886-35-1) + (+/-)-(2,2-difluoro-1,3-benzodioxol-4-yl)(4-methyl-1-piperazinyl)acetic acid hydrochloride (1092477-69-4) → (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,2-difluoro-1,3-benzodioxol-4-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide (1092476-50-0)

Guidance literature:

3,5-bis(trifluoromethyl)phenylhydrazine; (+/-)-(2,2-difluoro-1,3-benzodioxol-4-yl)(4-methyl-1-piperazinyl)acetic acid hydrochloride; With benzotriazol-1-ol; In 1-methyl-pyrrolidin-2-one; dichloromethane; at 20 ℃;

With PS-Trisamine; MP-isocyanate; In 1-methyl-pyrrolidin-2-one; dichloromethane; at 20 ℃; for 8h;

Reference yield:

(2,2-difluorobenzo[d][1,3]dioxol-4-yl)boronic acid (126120-87-4) → (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,2-difluoro-1,3-benzodioxol-4-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide (1092476-50-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 24 h / 80 °C

2.1: benzotriazol-1-ol / 1-methyl-pyrrolidin-2-one; dichloromethane / 20 °C

2.2: PS-trisamine; MP-isocyanate / 8 h / 20 °C

With benzotriazol-1-ol; In 1-methyl-pyrrolidin-2-one; dichloromethane; toluene;

Reference yield:

4-bromo-2,2-difluoro-1,3-benzodioxole (144584-66-7) → (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,2-difluoro-1,3-benzodioxol-4-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide (1092476-50-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 2 h / -78 - 20 °C

1.3: 0.33 h / 0 - 20 °C

2.1: toluene / 24 h / 80 °C

3.1: benzotriazol-1-ol / 1-methyl-pyrrolidin-2-one; dichloromethane / 20 °C

3.2: PS-trisamine; MP-isocyanate / 8 h / 20 °C

With n-butyllithium; benzotriazol-1-ol; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; dichloromethane; toluene;

upstream raw materials:

3,5-bis(trifluoromethyl)phenylhydrazine

(+/-)-(2,2-difluoro-1,3-benzodioxol-4-yl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

(2,2-difluorobenzo[d][1,3]dioxol-4-yl)boronic acid

4-bromo-2,2-difluoro-1,3-benzodioxole