methyl (E)-3-(3,5-dimethoxyphenyl)-2-(4-(4-((Z)-(2,4-dioxothiazolidine-5-ylidene)methyl)phenoxy)phenyl)acrylate

Base Information

Chemical Name:methyl (E)-3-(3,5-dimethoxyphenyl)-2-(4-(4-((Z)-(2,4-dioxothiazolidine-5-ylidene)methyl)phenoxy)phenyl)acrylate
CAS No.:606932-80-3
Molecular Formula:C₂₈H₂₃NO₇S
Molecular Weight:517.559
Hs Code.:

Synonyms:methyl (E)-3-(3,5-dimethoxyphenyl)-2-(4-(4-((Z)-(2,4-dioxothiazolidine-5-ylidene)methyl)phenoxy)phenyl)acrylate

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Chemical Property of methyl (E)-3-(3,5-dimethoxyphenyl)-2-(4-(4-((Z)-(2,4-dioxothiazolidine-5-ylidene)methyl)phenoxy)phenyl)acrylate

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Technology Process of methyl (E)-3-(3,5-dimethoxyphenyl)-2-(4-(4-((Z)-(2,4-dioxothiazolidine-5-ylidene)methyl)phenoxy)phenyl)acrylate

There total 4 articles about methyl (E)-3-(3,5-dimethoxyphenyl)-2-(4-(4-((Z)-(2,4-dioxothiazolidine-5-ylidene)methyl)phenoxy)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2295-31-0
thiazoline-2,4-dione

: 606932-79-0
3-(3,5-dimethoxyphenyl)-2-[4-(4-formylphenoxy)phenyl]acrylic acid methyl ester

: 606932-80-3
methyl (E)-3-(3,5-dimethoxyphenyl)-2-(4-(4-((Z)-(2,4-dioxothiazolidine-5-ylidene)methyl)phenoxy)phenyl)acrylate

Guidance literature:: With piperidine; benzoic acid; In toluene; for 5h; Heating;
DOI:10.1016/S0968-0896(03)00393-6

Reference yield:

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 606932-80-3
methyl (E)-3-(3,5-dimethoxyphenyl)-2-(4-(4-((Z)-(2,4-dioxothiazolidine-5-ylidene)methyl)phenoxy)phenyl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: 47 percent / acetic anhydride; triethylamine / 6 h / 130 - 140 °C

2: 97 percent / sulfuric acid / 20 h / Heating

3: 77 percent / sodium hydride / dimethylformamide / 18 h / 80 °C

4: 86 percent / benzoic acid; piperidine / toluene / 5 h / Heating

With piperidine; sulfuric acid; acetic anhydride; sodium hydride; triethylamine; benzoic acid; In N,N-dimethyl-formamide; toluene; 1: Perkin condensation / 4: Knoevenagel condensation;
DOI:10.1016/S0968-0896(03)00393-6

Reference yield:

: 116518-98-0
E-3-(3,5-dimethoxy-phenyl)-2-(4-hydroxy-phenyl)-acrylic Acid

: 606932-80-3
methyl (E)-3-(3,5-dimethoxyphenyl)-2-(4-(4-((Z)-(2,4-dioxothiazolidine-5-ylidene)methyl)phenoxy)phenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / sulfuric acid / 20 h / Heating

2: 77 percent / sodium hydride / dimethylformamide / 18 h / 80 °C

3: 86 percent / benzoic acid; piperidine / toluene / 5 h / Heating

With piperidine; sulfuric acid; sodium hydride; benzoic acid; In N,N-dimethyl-formamide; toluene; 3: Knoevenagel condensation;
DOI:10.1016/S0968-0896(03)00393-6