3(R)-{2-[(3S)-(tert-butyldimethylsilanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydrobenzo[e][1,4]diazepin-1-yl]acetylamino}-4-samicarbazone-butyric acid tert-butyl ester

Base Information

Chemical Name:3(R)-{2-[(3S)-(tert-butyldimethylsilanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydrobenzo[e][1,4]diazepin-1-yl]acetylamino}-4-samicarbazone-butyric acid tert-butyl ester
CAS No.:896746-88-6
Molecular Formula:C₃₃H₄₆N₆O₆Si
Molecular Weight:650.85
Hs Code.:

3(R)-{2-[(3S)-(tert-butyldimethylsilanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydrobenzo[e][1,4]diazepin-1-yl]acetylamino}-4-samicarbazone-butyric acid tert-butyl ester

Synonyms:3(R)-{2-[(3S)-(tert-butyldimethylsilanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydrobenzo[e][1,4]diazepin-1-yl]acetylamino}-4-samicarbazone-butyric acid tert-butyl ester

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Chemical Property of 3(R)-{2-[(3S)-(tert-butyldimethylsilanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydrobenzo[e][1,4]diazepin-1-yl]acetylamino}-4-samicarbazone-butyric acid tert-butyl ester

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Technology Process of 3(R)-{2-[(3S)-(tert-butyldimethylsilanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydrobenzo[e][1,4]diazepin-1-yl]acetylamino}-4-samicarbazone-butyric acid tert-butyl ester

There total 10 articles about 3(R)-{2-[(3S)-(tert-butyldimethylsilanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydrobenzo[e][1,4]diazepin-1-yl]acetylamino}-4-samicarbazone-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 896746-87-5
[(3R)-3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl]acetic acid

: 444608-34-8
C₉H₁₈N₄O₃

: 896746-88-6
3(R)-{2-[(3S)-(tert-butyldimethylsilanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydrobenzo[e][1,4]diazepin-1-yl]acetylamino}-4-samicarbazone-butyric acid tert-butyl ester

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1021/jm060405f

Reference yield:

: 896746-84-2
(R)-3-hydroxymethyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 896746-88-6
3(R)-{2-[(3S)-(tert-butyldimethylsilanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydrobenzo[e][1,4]diazepin-1-yl]acetylamino}-4-samicarbazone-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 87 percent / imidazole / CH₂Cl₂ / 12 h / 20 °C

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 78 percent / dimethylformamide / 5 h / 20 °C

3.1: 82 percent / aq. LiOH / methanol / 6 h / 0 - 20 °C

4.1: 2.38 g / ethyl(dimethylaminopropyl)carbodiimide; 1-hydroxybenzotriazole hydrate / dimethylformamide; CH₂Cl₂ / 15 h / 20 °C

With 1H-imidazole; lithium hydroxide; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060405f

Reference yield:

: 896746-85-3
(R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 896746-88-6
3(R)-{2-[(3S)-(tert-butyldimethylsilanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydrobenzo[e][1,4]diazepin-1-yl]acetylamino}-4-samicarbazone-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 78 percent / dimethylformamide / 5 h / 20 °C

2.1: 82 percent / aq. LiOH / methanol / 6 h / 0 - 20 °C

3.1: 2.38 g / ethyl(dimethylaminopropyl)carbodiimide; 1-hydroxybenzotriazole hydrate / dimethylformamide; CH₂Cl₂ / 15 h / 20 °C

With lithium hydroxide; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060405f