896746-84-2Relevant articles and documents
Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents
Micale, Nicola,Kozikowski, Alan P.,Ettari, Roberta,Grasso, Silvana,Zappalà, Maria,Jeong, Jong-Jin,Kumar, Ajay,Hanspal, Manjit,Chishti, Athar H.
, p. 3064 - 3067 (2006)
The synthesis of a new class of peptidomimetics 1a-j, based on a 1,4-benzodiazepine scaffold and on a C-terminal aspartyl aldehyde building block, is described. Compounds 1a-j provided significant inhibitory activity against falcipains 2A and 2B (FP-2A an
NMR characterization and conformational analysis of a potent papain-family cathepsin L-like cysteine protease inhibitor with different behaviour in polar and apolar media
Rotondo, Archimede,Ettari, Roberta,Zappalà, Maria,De Micheli, Carlo,Rotondo, Enrico
, p. 337 - 343 (2015/01/16)
We recently reported the synthesis, of a potent papain-family cathepsin L-like cysteine protease inhibitor, as new lead compound for the development of new drugs that can be used as antiprotozoal agents. The investigation of its conformational profile is