4-(3-chloro-2-fluoroanilino)-6-{[1-(N,N-dimethylcarbamoylmethyl)piperidin-4-yl]oxy}-7-methoxyquinazoline

Base Information

Chemical Name:4-(3-chloro-2-fluoroanilino)-6-{[1-(N,N-dimethylcarbamoylmethyl)piperidin-4-yl]oxy}-7-methoxyquinazoline
CAS No.:848942-78-9
Molecular Formula:C₂₄H₂₇ClFN₅O₃
Molecular Weight:487.961
Hs Code.:

Synonyms:4-(3-chloro-2-fluoroanilino)-6-{[1-(N,N-dimethylcarbamoylmethyl)piperidin-4-yl]oxy}-7-methoxyquinazoline

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Chemical Property of 4-(3-chloro-2-fluoroanilino)-6-{[1-(N,N-dimethylcarbamoylmethyl)piperidin-4-yl]oxy}-7-methoxyquinazoline

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Technology Process of 4-(3-chloro-2-fluoroanilino)-6-{[1-(N,N-dimethylcarbamoylmethyl)piperidin-4-yl]oxy}-7-methoxyquinazoline

There total 6 articles about 4-(3-chloro-2-fluoroanilino)-6-{[1-(N,N-dimethylcarbamoylmethyl)piperidin-4-yl]oxy}-7-methoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 612500-78-4
N-(3-chloro-2-fluorophenyl)-7-methoxy-6-(piperidin-4-yloxy)quinazolin-4-amine

: 2675-89-0
2-chloro-N,N-dimethylacetamide

: 848942-78-9
4-(3-chloro-2-fluoroanilino)-6-{[1-(N,N-dimethylcarbamoylmethyl)piperidin-4-yl]oxy}-7-methoxyquinazoline

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 1h; Reflux; Inert atmosphere;
DOI:10.1021/ml400146c

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 848942-78-9
4-(3-chloro-2-fluoroanilino)-6-{[1-(N,N-dimethylcarbamoylmethyl)piperidin-4-yl]oxy}-7-methoxyquinazoline

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl alcohol / 3 h / 80 °C / Inert atmosphere

2: ammonium hydroxide / methanol / 2 h / 50 °C / Inert atmosphere

3: cesium fluoride / N,N-dimethyl acetamide / 12 h / 85 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

5: potassium iodide; potassium carbonate / acetonitrile / 1 h / Reflux; Inert atmosphere

With ammonium hydroxide; potassium carbonate; cesium fluoride; trifluoroacetic acid; potassium iodide; In methanol; dichloromethane; N,N-dimethyl acetamide; isopropyl alcohol; acetonitrile;
DOI:10.1021/ml400146c

Reference yield:

: 612501-80-1
4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl acetate monohydrochloride

: 848942-78-9
4-(3-chloro-2-fluoroanilino)-6-{[1-(N,N-dimethylcarbamoylmethyl)piperidin-4-yl]oxy}-7-methoxyquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium hydroxide / methanol / 2 h / 50 °C / Inert atmosphere

2: cesium fluoride / N,N-dimethyl acetamide / 12 h / 85 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: potassium iodide; potassium carbonate / acetonitrile / 1 h / Reflux; Inert atmosphere

With ammonium hydroxide; potassium carbonate; cesium fluoride; trifluoroacetic acid; potassium iodide; In methanol; dichloromethane; N,N-dimethyl acetamide; acetonitrile;
DOI:10.1021/ml400146c