N-[4-[1-hydroxy-2-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide

Base Information

• Chemical Name: N-[4-[1-hydroxy-2-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide
• CAS No.: 129872-66-8
• Molecular Formula: C₂₀H₂₄N₄O₄S
• Molecular Weight: 416.501

Synonyms:N-[4-[1-hydroxy-2-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide

Chemical Property of N-[4-[1-hydroxy-2-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide

Chemical Property:

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Technology Process of N-[4-[1-hydroxy-2-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide

There total 4 articles about N-[4-[1-hydroxy-2-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[4-[2-[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-1-oxoethyl]phenyl]methanesulfonamide (128263-79-6) → N-[4-[1-hydroxy-2-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide (129872-66-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium dihydroxide; for 8h; under 2585.7 Torr; Ambient temperature;

DOI:10.1021/jm00172a033

Reference yield:

N-[4-(2-bromoacetyl)phenyl]methanesulfonamide (5577-42-4) → N-[4-[1-hydroxy-2-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide (129872-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-diisopropylethylamine / acetonitrile / 17 h / Ambient temperature

2: H₂, 1 N HCl / Pd(OH)2/C / 8 h / 2585.7 Torr / Ambient temperature

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In acetonitrile;

DOI:10.1021/jm00172a033

Reference yield:

2-<4-(1H-imidazol-1-yl)phenoxy>-N-(phenylmethyl)ethanamine dihydrochloride (122958-27-4,128263-76-3) → N-[4-[1-hydroxy-2-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide (129872-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-diisopropylethylamine / acetonitrile / 17 h / Ambient temperature

2: H₂, 1 N HCl / Pd(OH)2/C / 8 h / 2585.7 Torr / Ambient temperature

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In acetonitrile;

DOI:10.1021/jm00172a033

upstream raw materials:

N-[4-[2-[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-1-oxoethyl]phenyl]methanesulfonamide

N-[4-(2-bromoacetyl)phenyl]methanesulfonamide

2-<4-(1H-imidazol-1-yl)phenoxy>-N-(phenylmethyl)ethanamine dihydrochloride

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