Technology Process of 2-iodo-5-fluoro-3-methylbenzoic acid
There total 3 articles about 2-iodo-5-fluoro-3-methylbenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-amino-5-fluoro-3-methylbenzoic acid;
With
hydrogenchloride;
In
water;
at 0 ℃;
for 0.25h;
With
sodium nitrite;
In
water;
for 0.166667h;
Cooling with ice;
With
potassium iodide;
In
water;
at 20 ℃;
for 16h;
DOI:10.1021/jo302393u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium nitrate; sulfuric acid / water / 1 h / 20 °C
2.1: tin(ll) chloride / ethanol / 0.5 h / 70 °C
3.1: hydrogenchloride / water / 0.25 h / 0 °C
3.2: 0.17 h / Cooling with ice
3.3: 16 h / 20 °C
With
hydrogenchloride; sulfuric acid; potassium nitrate; tin(ll) chloride;
In
ethanol; water;
DOI:10.1021/jo302393u
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tin(ll) chloride / ethanol / 0.5 h / 70 °C
2.1: hydrogenchloride / water / 0.25 h / 0 °C
2.2: 0.17 h / Cooling with ice
2.3: 16 h / 20 °C
With
hydrogenchloride; tin(ll) chloride;
In
ethanol; water;
DOI:10.1021/jo302393u
