3-Bromo-4-chloro-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:3-Bromo-4-chloro-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:744209-65-2
Molecular Formula:C₁₄H₁₀BrClN₂O₂S
Molecular Weight:385.669
Hs Code.:
DSSTox Substance ID:DTXSID001153436

Synonyms:DTXSID001153436;3-Bromo-4-chloro-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine;744209-65-2

Suppliers and Price of 3-Bromo-4-chloro-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Bromo-4-chloro-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:383.93349
Heavy Atom Count:21
Complexity:478

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C2=C(C=CN=C2N1S(=O)(=O)C3=CC=CC=C3)Cl)Br

Technology Process of 3-Bromo-4-chloro-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

There total 4 articles about 3-Bromo-4-chloro-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 744209-64-1
4-chloro-2-methyl-1-(o-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 744209-65-2
3-bromo-4-chloro-1-phenylsulfonyl-2-methylpyrrolo[2,3-b]pyridine

Guidance literature:: With N-Bromosuccinimide; In tetrachloromethane; at 20 ℃; for 12h;
DOI:10.1021/jo0358168

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 744209-65-2
3-bromo-4-chloro-1-phenylsulfonyl-2-methylpyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / benzyltriethylammonium chloride; NaOH / CH₂Cl₂ / 0 - 20 °C

2.1: LDA / tetrahydrofuran / 0.67 h / -30 °C

2.2: 85 percent / tetrahydrofuran / 16 h / 20 °C

3.1: 81 percent / NBS / CCl₄ / 12 h / 20 °C

With sodium hydroxide; N-Bromosuccinimide; N-benzyl-N,N,N-triethylammonium chloride; lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1021/jo0358168

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 744209-65-2
3-bromo-4-chloro-1-phenylsulfonyl-2-methylpyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / benzyltriethylammonium chloride; NaOH / CH₂Cl₂ / 0 - 20 °C

2.1: LDA / tetrahydrofuran / 0.67 h / -30 °C

2.2: 85 percent / tetrahydrofuran / 16 h / 20 °C

3.1: 81 percent / NBS / CCl₄ / 12 h / 20 °C

With sodium hydroxide; N-Bromosuccinimide; N-benzyl-N,N,N-triethylammonium chloride; lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1021/jo0358168