(+/-)-α-[2-methoxy-3-[(1,1-dimethylethyl)diphenylsilyl]oxyphenyl]-4-piperidinemethanol

Base Information

Chemical Name:(+/-)-α-[2-methoxy-3-[(1,1-dimethylethyl)diphenylsilyl]oxyphenyl]-4-piperidinemethanol
CAS No.:311348-75-1
Molecular Formula:C₂₉H₃₇NO₃Si
Molecular Weight:475.703
Hs Code.:

Synonyms:(+/-)-α-[2-methoxy-3-[(1,1-dimethylethyl)diphenylsilyl]oxyphenyl]-4-piperidinemethanol

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Chemical Property of (+/-)-α-[2-methoxy-3-[(1,1-dimethylethyl)diphenylsilyl]oxyphenyl]-4-piperidinemethanol

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Technology Process of (+/-)-α-[2-methoxy-3-[(1,1-dimethylethyl)diphenylsilyl]oxyphenyl]-4-piperidinemethanol

There total 8 articles about (+/-)-α-[2-methoxy-3-[(1,1-dimethylethyl)diphenylsilyl]oxyphenyl]-4-piperidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: (3-((tert-butyldiphenylsilyl)oxy)-2-methoxyphenyl)(piperidin-4-yl)methanone

: 311348-75-1
(+/-)-α-[2-methoxy-3-[(1,1-dimethylethyl)diphenylsilyl]oxyphenyl]-4-piperidinemethanol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2018.02.058

Reference yield:

: 108534-61-8
(2-methoxyphenoxy)-(1,1-dimethylethyl)diphenylsilane

: 311348-75-1
(+/-)-α-[2-methoxy-3-[(1,1-dimethylethyl)diphenylsilyl]oxyphenyl]-4-piperidinemethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / hexane / 2 h

1.2: 61 percent / hexane / -50 - 20 °C

2.1: TFA / 0.5 h / 25 - 30 °C

3.1: NaBH₄ / methanol / 25 - 30 °C

With sodium tetrahydroborate; n-butyllithium; trifluoroacetic acid; In methanol; hexane; 1.1: Metallation / 1.2: Substitution / 2.1: carbamate cleavage / 3.1: Reduction;
DOI:10.1016/S0968-0896(00)00175-9

Reference yield:

: 139290-70-3
tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

: 311348-75-1
(+/-)-α-[2-methoxy-3-[(1,1-dimethylethyl)diphenylsilyl]oxyphenyl]-4-piperidinemethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / hexane / 2 h

1.2: 61 percent / hexane / -50 - 20 °C

2.1: TFA / 0.5 h / 25 - 30 °C

3.1: NaBH₄ / methanol / 25 - 30 °C

With sodium tetrahydroborate; n-butyllithium; trifluoroacetic acid; In methanol; hexane; 1.1: Metallation / 1.2: Substitution / 2.1: carbamate cleavage / 3.1: Reduction;
DOI:10.1016/S0968-0896(00)00175-9