N-benzyl monoaza-21-crown-7

Base Information

• Chemical Name: N-benzyl monoaza-21-crown-7
• CAS No.: 205248-60-8
• Molecular Formula: C₂₁H₃₅NO₆
• Molecular Weight: 397.512
• Mol file: 205248-60-8.mol

Synonyms:N-benzyl monoaza-21-crown-7

Chemical Property of N-benzyl monoaza-21-crown-7

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-benzyl monoaza-21-crown-7

There total 2 articles about N-benzyl monoaza-21-crown-7 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

N-benzyl-diethanolamine (101-32-6) + penta(ethylene glycol) bis(p-toluenesulfonate) (41024-91-3) → N-benzyl monoaza-21-crown-7 (205248-60-8)

Guidance literature:

With cesium chloride; tetrabutylammomium bromide; sodium hydroxide; In water; benzene; at 70 ℃; for 15h; Reagent/catalyst;

DOI:10.1134/S1070428012100156

Reference yield:

Pentaethylene glycol (4792-15-8) → N-benzyl monoaza-21-crown-7 (205248-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane; water / 6.5 h

2: sodium hydroxide; tetrabutylammomium bromide; cesium chloride / water; benzene / 15 h / 70 °C

With cesium chloride; tetrabutylammomium bromide; N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In dichloromethane; water; benzene;

DOI:10.1134/S1070428012100156

Reference yield: 93.0%

N-benzyl monoaza-21-crown-7 (205248-60-8) → 1,4,7,10,13,16-hexaoxa-19-azacycloheneicosane (66843-21-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 12h;

DOI:10.1016/j.dyepig.2015.05.020

upstream raw materials:

N-benzyl-diethanolamine

penta(ethylene glycol) bis(p-toluenesulfonate)

Pentaethylene glycol

Downstream raw materials:

1,4,7,10,13,16-hexaoxa-19-azacycloheneicosane