methyl 2-(1-(4-chlorobenzoyl)-5-fluoro-1H-indol-3-yl)acetate

Base Information

• Chemical Name: methyl 2-(1-(4-chlorobenzoyl)-5-fluoro-1H-indol-3-yl)acetate
• CAS No.: 1412449-51-4
• Molecular Formula: C₁₈H₁₃ClFNO₃
• Molecular Weight: 345.758
• Mol file: 1412449-51-4.mol

Synonyms:methyl 2-(1-(4-chlorobenzoyl)-5-fluoro-1H-indol-3-yl)acetate

Chemical Property of methyl 2-(1-(4-chlorobenzoyl)-5-fluoro-1H-indol-3-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 2-(1-(4-chlorobenzoyl)-5-fluoro-1H-indol-3-yl)acetate

There total 1 articles about methyl 2-(1-(4-chlorobenzoyl)-5-fluoro-1H-indol-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

4-chloro-benzoyl chloride (122-01-0) + methyl 2-(5-fluoro-1H-indol-3-yl)acetate (497258-29-4) → methyl 2-(1-(4-chlorobenzoyl)-5-fluoro-1H-indol-3-yl)acetate (1412449-51-4)

Guidance literature:

methyl 2-(5-fluoro-1H-indol-3-yl)acetate; With sodium t-butanolate; In tetrahydrofuran; at 0 - 5 ℃; for 0.416667h;

4-chloro-benzoyl chloride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tet.2012.08.044 DOI:10.1016/j.tet.2012.08.044

Reference yield: 78.0%

methyl 2-(1-(4-chlorobenzoyl)-5-fluoro-1H-indol-3-yl)acetate (1412449-51-4) → 2-(1-(4-chlorobenzoyl)-5-fluoro-1H-indol-3-yl)acetic acid (1412449-63-8)

Guidance literature:

With trimethyl-tin hydroxide; In 1,2-dichloro-ethane; at 130 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.tet.2012.08.044 DOI:10.1016/j.tet.2012.08.044

upstream raw materials:

4-chloro-benzoyl chloride

methyl 2-(5-fluoro-1H-indol-3-yl)acetate

Downstream raw materials:

2-(1-(4-chlorobenzoyl)-5-fluoro-1H-indol-3-yl)acetic acid