4-iodo-1-methyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1H-imidazole-5-carboxamide

Base Information

Chemical Name:4-iodo-1-methyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1H-imidazole-5-carboxamide
CAS No.:1446442-60-9
Molecular Formula:C₁₂H₅F₇IN₃O
Molecular Weight:467.085
Hs Code.:

Synonyms:4-iodo-1-methyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1H-imidazole-5-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-iodo-1-methyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1H-imidazole-5-carboxamide

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Technology Process of 4-iodo-1-methyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1H-imidazole-5-carboxamide

There total 2 articles about 4-iodo-1-methyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1H-imidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1446442-90-5
1-methyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1H-imidazole-5-carboxamide

: 1446442-60-9
4-iodo-1-methyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1H-imidazole-5-carboxamide

Guidance literature:: With iodine; cesium acetate; palladium diacetate; sodium hydrogencarbonate; In dimethyl sulfoxide; at 65 ℃; for 36h; Molecular sieve; Sealed tube; Sonication;
DOI:10.1021/ja4055492

Reference yield:

: 651-83-2
4-trifluoromethyl-2,3,5,6-tetrafluoroaniline

: 41716-12-5
3-methyl-3H-imidazole-4-carbonyl chloride

: 1446442-60-9
4-iodo-1-methyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1H-imidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / Reflux; Inert atmosphere

2: palladium diacetate; cesium acetate; sodium hydrogencarbonate; iodine / dimethyl sulfoxide / 36 h / 65 °C / Molecular sieve; Sealed tube; Sonication

With iodine; cesium acetate; palladium diacetate; sodium hydrogencarbonate; In dimethyl sulfoxide; toluene;
DOI:10.1021/ja4055492