N-[(2R,3R,4S,5S,6R)-4-Allyloxy-2-benzyloxy-5-hydroxy-6-(4-methoxy-phenoxymethyl)-tetrahydro-pyran-3-yl]-acetamide

Base Information

Chemical Name:N-[(2R,3R,4S,5S,6R)-4-Allyloxy-2-benzyloxy-5-hydroxy-6-(4-methoxy-phenoxymethyl)-tetrahydro-pyran-3-yl]-acetamide
CAS No.:203435-13-6
Molecular Formula:C₂₅H₃₁NO₇
Molecular Weight:457.524
Hs Code.:

Synonyms:N-[(2R,3R,4S,5S,6R)-4-Allyloxy-2-benzyloxy-5-hydroxy-6-(4-methoxy-phenoxymethyl)-tetrahydro-pyran-3-yl]-acetamide

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Chemical Property of N-[(2R,3R,4S,5S,6R)-4-Allyloxy-2-benzyloxy-5-hydroxy-6-(4-methoxy-phenoxymethyl)-tetrahydro-pyran-3-yl]-acetamide

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Technology Process of N-[(2R,3R,4S,5S,6R)-4-Allyloxy-2-benzyloxy-5-hydroxy-6-(4-methoxy-phenoxymethyl)-tetrahydro-pyran-3-yl]-acetamide

There total 3 articles about N-[(2R,3R,4S,5S,6R)-4-Allyloxy-2-benzyloxy-5-hydroxy-6-(4-methoxy-phenoxymethyl)-tetrahydro-pyran-3-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 150-76-5
4-methoxy-phenol

: 203435-11-4
N-((2R,3R,4S,5S,6R)-4-Allyloxy-2-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl)-acetamide

: 203435-13-6
N-[(2R,3R,4S,5S,6R)-4-Allyloxy-2-benzyloxy-5-hydroxy-6-(4-methoxy-phenoxymethyl)-tetrahydro-pyran-3-yl]-acetamide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 70 ℃; for 1h;
DOI:10.1021/jo971784a

Reference yield:

: 176300-16-6
benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-β-D-allopyranoside

: 203435-13-6
N-[(2R,3R,4S,5S,6R)-4-Allyloxy-2-benzyloxy-5-hydroxy-6-(4-methoxy-phenoxymethyl)-tetrahydro-pyran-3-yl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, room temperature, 1 h

2: 91 percent / camphorsulfonic acid / methanol / 1 h / 60 °C

3: 90 percent / triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / 1 h / 70 °C

With di-isopropyl azodicarboxylate; camphor-10-sulfonic acid; sodium hydride; triphenylphosphine; In tetrahydrofuran; methanol;
DOI:10.1021/jo971784a

Reference yield:

: 203435-10-3
N-((2R,4aR,6R,7R,8S,8aS)-8-Allyloxy-6-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-acetamide

: 203435-13-6
N-[(2R,3R,4S,5S,6R)-4-Allyloxy-2-benzyloxy-5-hydroxy-6-(4-methoxy-phenoxymethyl)-tetrahydro-pyran-3-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / camphorsulfonic acid / methanol / 1 h / 60 °C

2: 90 percent / triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / 1 h / 70 °C

With di-isopropyl azodicarboxylate; camphor-10-sulfonic acid; triphenylphosphine; In tetrahydrofuran; methanol;
DOI:10.1021/jo971784a