methyl N^α-benzyloxycarbonylamino-γ-nitrobutyrate

Base Information

• Chemical Name: methyl N^α-benzyloxycarbonylamino-γ-nitrobutyrate
• CAS No.: 81546-71-6
• Molecular Formula: C₁₃H₁₆N₂O₆
• Molecular Weight: 296.28
• Mol file: 81546-71-6.mol

Synonyms:methyl N^α-benzyloxycarbonylamino-γ-nitrobutyrate

Chemical Property of methyl N^α-benzyloxycarbonylamino-γ-nitrobutyrate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl N^α-benzyloxycarbonylamino-γ-nitrobutyrate

There total 3 articles about methyl N^α-benzyloxycarbonylamino-γ-nitrobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

nitromethane (75-52-5) + methyl 2-(benzyloxycarbonylamino)acrylate (21149-17-7) → methyl Nα-benzyloxycarbonylamino-γ-nitrobutyrate (81546-71-6)

Guidance literature:

With potassium fluoride; for 14h; Heating;

Reference yield: 32.0%

2-<(benzyloxycarbonyl)amino>-4-bromobutanoic acid methyl ester (76338-91-5) → methyl Nα-benzyloxycarbonylamino-γ-nitrobutyrate (81546-71-6)

Guidance literature:

With sodium nitrite; In dimethyl sulfoxide; at 20 ℃; for 20h;

Reference yield: 31.0%

methyl Nα-benzyloxycarbonylamino-γ-iodobutyrate (81546-70-5) → methyl Nα-benzyloxycarbonylamino-γ-nitrobutyrate (81546-71-6)

Guidance literature:

With sodium nitrite; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

upstream raw materials:

2-<(benzyloxycarbonyl)amino>-4-bromobutanoic acid methyl ester

methyl N^α-benzyloxycarbonylamino-γ-iodobutyrate

nitromethane

methyl 2-(benzyloxycarbonylamino)acrylate

Downstream raw materials:

dicyclohexylammonium N^α-benzyloxycarbonylamino-γ-nitrobutyrate

2-amino-4-nitro-butyric acid methyl ester

2-{4-[(2-acetylamino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-formyl-amino]-benzoylamino}-4-nitro-butyric acid methyl ester

2-[N-[4-[N-[(2-acetamido-4(3H)oxopyrido[2,3-d]pyrimidin-6-yl)methyl]formamido]benzoyl]amino]-4-nitrobutanoic acid methyl ester