N-(4-methoxybenzyl)-N'-methyl-N'-(2-(N-phthalimido)ethyl)-N-2-pyridinyl-1,2-ethanediamine

Base Information

Chemical Name:N-(4-methoxybenzyl)-N'-methyl-N'-(2-(N-phthalimido)ethyl)-N-2-pyridinyl-1,2-ethanediamine
CAS No.:109912-30-3
Molecular Formula:C₂₆H₂₈N₄O₃
Molecular Weight:444.533
Hs Code.:

Synonyms:N-(4-methoxybenzyl)-N'-methyl-N'-(2-(N-phthalimido)ethyl)-N-2-pyridinyl-1,2-ethanediamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-methoxybenzyl)-N'-methyl-N'-(2-(N-phthalimido)ethyl)-N-2-pyridinyl-1,2-ethanediamine

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Technology Process of N-(4-methoxybenzyl)-N'-methyl-N'-(2-(N-phthalimido)ethyl)-N-2-pyridinyl-1,2-ethanediamine

There total 5 articles about N-(4-methoxybenzyl)-N'-methyl-N'-(2-(N-phthalimido)ethyl)-N-2-pyridinyl-1,2-ethanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 574-98-1
2-(2-bromoethyl)isoindoline-1,3-dione

: 104499-47-0
N-Desmethylpyrilamine

: 109912-30-3
N-(4-methoxybenzyl)-N'-methyl-N'-(2-(N-phthalimido)ethyl)-N-2-pyridinyl-1,2-ethanediamine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2.5h;
DOI:10.1016/0223-5234(87)90002-X

Reference yield:

: 109-04-6
2-bromo-pyridine

: 109912-30-3
N-(4-methoxybenzyl)-N'-methyl-N'-(2-(N-phthalimido)ethyl)-N-2-pyridinyl-1,2-ethanediamine

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / pyridine / 5 h / Heating

2: 71 percent / sodium hydride / dimethylsulfoxide / 1.) below 40 deg C, 20 min, 2.) 22 deg C, 45 min

3: 91 percent / acetic anhydride / diethyl ether / 16 h / 22 °C

4: 95 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

5: 32 percent / potassium carbonate / dimethylformamide / 2.5 h / 100 °C

With lithium aluminium tetrahydride; acetic anhydride; sodium hydride; potassium carbonate; In tetrahydrofuran; pyridine; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(87)90002-X

Reference yield:

: 74764-17-3
2-[(pyridin-2-yl)amino]ethylamine

: 109912-30-3
N-(4-methoxybenzyl)-N'-methyl-N'-(2-(N-phthalimido)ethyl)-N-2-pyridinyl-1,2-ethanediamine

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / sodium hydride / dimethylsulfoxide / 1.) below 40 deg C, 20 min, 2.) 22 deg C, 45 min

2: 91 percent / acetic anhydride / diethyl ether / 16 h / 22 °C

3: 95 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

4: 32 percent / potassium carbonate / dimethylformamide / 2.5 h / 100 °C

With lithium aluminium tetrahydride; acetic anhydride; sodium hydride; potassium carbonate; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(87)90002-X