N-2-Pyridinyl-1,2-ethanediamine

Base Information

• Chemical Name: N-2-Pyridinyl-1,2-ethanediamine
• CAS No.: 74764-17-3
• Molecular Formula: C7H11 N3
• Molecular Weight: 137.184
• Hs Code.: 2933399090
• Mol file: 74764-17-3.mol

Synonyms:1,2-Ethanediamine,N-2-pyridinyl- (9CI); Pyridine, 2-[(2-aminoethyl)amino]- (6CI,7CI);2-(2-Pyridylamino)ethylamine; 2-[(2-Aminoethyl)amino]pyridine;N-(2-Aminoethyl)pyridine-2-amine; N-(2-Pyridinyl)ethylenediamine;N-(2-Pyridyl)ethylenediamine;N-Pyridin-2-ylethane-1,2-diamine; N1-Pyridin-2-ylethane-1,2-diamine; NSC 28695

Chemical Property of N-2-Pyridinyl-1,2-ethanediamine

Chemical Property:

• Vapor Pressure: 0.00183mmHg at 25°C
• Melting Point: 45-47°C
• Boiling Point: 93-95°C/0.5 Torr
• PKA: 9.19±0.10(Predicted)
• Flash Point: 130.7°C
• PSA: 50.94000
• Density: 1.121g/cm³
• LogP: 1.22550
• Storage Temp.: -20°C Freezer

Purity/Quality:

98%min ^*data from raw suppliers

N-2-Pyridinyl-1,2-ethanediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-2-Pyridinyl-1,2-ethanediamine is a reactant used in the synthesis of dual histamine H1 and H2 receptor antagonists based on cyanoguanidine. Also used in the synthesis of 2-thiohydantoins as somatostatin receptor ligands,

Technology Process of N-2-Pyridinyl-1,2-ethanediamine

There total 10 articles about N-2-Pyridinyl-1,2-ethanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.3%

2-bromo-pyridine (109-04-6) + ethylenediamine (107-15-3,85404-18-8) → 2-[(pyridin-2-yl)amino]ethylamine (74764-17-3)

Guidance literature:

With pyridine; at 90 ℃; for 12h;

Reference yield: 83.0%

2-chloropyridine (109-09-1) + ethylenediamine (107-15-3,85404-18-8) → 2-[(pyridin-2-yl)amino]ethylamine (74764-17-3)

Guidance literature:

Inert atmosphere; Reflux;

DOI:10.1039/b809038f

Reference yield: 71.0%

2-aminopyridine (504-29-0) + ethanolamine (141-43-5) → 2-[(pyridin-2-yl)amino]ethylamine (74764-17-3)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; Py₂NPiPr₂; sodium t-butanolate; In tetrahydrofuran; diethylene glycol dimethyl ether; at 110 ℃; for 24h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/adsc.200900548

upstream raw materials:

2-bromo-pyridine

ethylenediamine

2-chloropyridine

2-fluoropyridine

Downstream raw materials:

ethyl 2-[4-[2-(2-pyridylamino)ethylamino]cyclohexyl]acetate

ethyl 2-[4-[2-(2-pyridylamino)ethylamino]cyclohexyl]acetate

C₁₇H₂₃FN₄

N-[2-[N-(4-methoxybenzyl)-N-(pyridin-2-yl)amino]ethyl]-N-methyl-1,2-ethanediamine

Refernces

• 1、 Kumpina, Ilze,Brodyagin, Nikita,Mackay, James A.,Kennedy, Scott D.,Katkevics, Martins,Rozners, Eriks. "Synthesis and RNA-Binding Properties of Extended Nucleobases for Triplex-Forming Peptide Nucleic Acids". . p. 13276 - 13298. Retrieved 2019/10/16.
• 2、 Sadek, Bassem,Alisch, Rudi,Buschauer, Armin,Elz, Sigurd. "Synthesis and dual histamine H1 and H2 receptor antagonist activity of cyanoguanidine derivatives". . p. 14186 - 14202. Retrieved 2014/01/06.