tetra-n-butylammonium salt of 4-amino-5-chloro-N-<2-(diethylamino)ethyl>-2-hydroxybenzamide

Base Information

• Chemical Name: tetra-n-butylammonium salt of 4-amino-5-chloro-N-<2-(diethylamino)ethyl>-2-hydroxybenzamide
• CAS No.: 102670-98-4
• Molecular Formula: C₁₃H₁₉ClN₃O₂*C₁₆H₃₆N
• Molecular Weight: 527.234
• Mol file: 102670-98-4.mol

Synonyms:tetra-n-butylammonium salt of 4-amino-5-chloro-N-<2-(diethylamino)ethyl>-2-hydroxybenzamide

Chemical Property of tetra-n-butylammonium salt of 4-amino-5-chloro-N-<2-(diethylamino)ethyl>-2-hydroxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tetra-n-butylammonium salt of 4-amino-5-chloro-N-<2-(diethylamino)ethyl>-2-hydroxybenzamide

There total 2 articles about tetra-n-butylammonium salt of 4-amino-5-chloro-N-<2-(diethylamino)ethyl>-2-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

tetra(n-butyl)ammonium hydrogensulfate (32503-27-8) + 4-amino-5-chloro-N-<2-(diethylamino)ethyl>-2-hydroxybenzamide hydrochloride (38059-78-8) → tetra-n-butylammonium salt of 4-amino-5-chloro-N-<2-(diethylamino)ethyl>-2-hydroxybenzamide (102670-98-4)

Guidance literature:

With sodium hydroxide; In water;

DOI:10.1021/jm00403a011

Reference yield:

metoclopramide (364-62-5) → tetra-n-butylammonium salt of 4-amino-5-chloro-N-<2-(diethylamino)ethyl>-2-hydroxybenzamide (102670-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium hydride, ethanethiol, 2.) conc.HCl / 1.) DMF, 100-105 deg C, 90 min

2: 87 percent / NaOH / H₂O

With hydrogenchloride; sodium hydroxide; sodium hydride; ethanethiol; In water;

DOI:10.1021/jm00403a011

Reference yield: 87.0%

5-(bromomethyl)-3-methyl-1,2-oxazole (36958-61-9) + tetra-n-butylammonium salt of 4-amino-5-chloro-N-<2-(diethylamino)ethyl>-2-hydroxybenzamide (102670-98-4) → 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-(3-methylisoxazol-5-yl)methoxybenzamide (102670-57-5)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1021/jm00403a011

upstream raw materials:

tetra(n-butyl)ammonium hydrogensulfate

4-amino-5-chloro-N-<2-(diethylamino)ethyl>-2-hydroxybenzamide hydrochloride

metoclopramide

Downstream raw materials:

4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(tetrahydro-furan-2-ylmethoxy)-benzamide; hydrochloride

4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(4-methylsulfanyl-butoxy)-benzamide

4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-oxo-cyclohexyloxy)-benzamide

4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(pyridin-2-ylmethoxy)-benzamide