10-O-cyclopropanecarbonyl-10-O-deacetyl-2-O-debenzoyl-2-O-(3-fluorobenzoyl)-7-O-triethylsilylbaccatin III

Base Information

Chemical Name:10-O-cyclopropanecarbonyl-10-O-deacetyl-2-O-debenzoyl-2-O-(3-fluorobenzoyl)-7-O-triethylsilylbaccatin III
CAS No.:1007094-35-0
Molecular Formula:C₃₉H₅₃FO₁₁Si
Molecular Weight:744.927
Hs Code.:

Synonyms:10-O-cyclopropanecarbonyl-10-O-deacetyl-2-O-debenzoyl-2-O-(3-fluorobenzoyl)-7-O-triethylsilylbaccatin III

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Chemical Property of 10-O-cyclopropanecarbonyl-10-O-deacetyl-2-O-debenzoyl-2-O-(3-fluorobenzoyl)-7-O-triethylsilylbaccatin III

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Technology Process of 10-O-cyclopropanecarbonyl-10-O-deacetyl-2-O-debenzoyl-2-O-(3-fluorobenzoyl)-7-O-triethylsilylbaccatin III

There total 7 articles about 10-O-cyclopropanecarbonyl-10-O-deacetyl-2-O-debenzoyl-2-O-(3-fluorobenzoyl)-7-O-triethylsilylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 1007094-35-0
10-O-cyclopropanecarbonyl-10-O-deacetyl-2-O-debenzoyl-2-O-(3-fluorobenzoyl)-7-O-triethylsilylbaccatin III

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / -10 °C

3: diisopropyl-carbodiimide; dmap / dichloromethane

4: pyridine; hydrogen fluoride / acetonitrile

5: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

6: lithium hexamethyldisilazane / tetrahydrofuran

With pyridine; 1H-imidazole; dmap; hydrogen fluoride; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium hexamethyldisilazane; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: 994-30-9
triethylsilyl chloride

: 1007094-35-0
10-O-cyclopropanecarbonyl-10-O-deacetyl-2-O-debenzoyl-2-O-(3-fluorobenzoyl)-7-O-triethylsilylbaccatin III

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran

With 1H-imidazole; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: 194720-19-9
7,10,13-tris(triethylsilyl)-10-deacetylbaccatin III

: 1007094-35-0
10-O-cyclopropanecarbonyl-10-O-deacetyl-2-O-debenzoyl-2-O-(3-fluorobenzoyl)-7-O-triethylsilylbaccatin III

Guidance literature:: Multi-step reaction with 5 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / -10 °C

2: diisopropyl-carbodiimide; dmap / dichloromethane

3: pyridine; hydrogen fluoride / acetonitrile

4: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

5: lithium hexamethyldisilazane / tetrahydrofuran

With pyridine; 1H-imidazole; dmap; hydrogen fluoride; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium hexamethyldisilazane; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007