(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester

Base Information

Chemical Name:(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester
CAS No.:234122-43-1
Molecular Formula:C₂₃H₃₃IN₄O₅
Molecular Weight:572.443
Hs Code.:

Synonyms:(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester

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Chemical Property of (S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester

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Technology Process of (S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester

There total 9 articles about (S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 234122-61-3
(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester

: 234122-43-1
(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 25 ℃; for 2h;

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 234122-43-1
(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / DBU / CH₂Cl₂ / 2 h / 25 °C

2: 90 percent / H₂ / <(S,S)-Et-DuP-Rh>(+)TfO(-) / 96 h / 3102.89 Torr

3: 96 percent / H₂ / 10 percent Pd/C / methanol / 12 h / 25 °C

4: 78 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxy-7-azabenzotriazole / CH₂Cl₂ / 3 h / 0 - 25 °C

5: 89 percent / LiOH, H₂O / tetrahydrofuran / 1.5 h / 0 - 25 °C

6: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxy-7-azabenzotriazole, i-Pr₂NEt / CH₂Cl₂ / 3.5 h / 0 - 25 °C

7: TFA / CH₂Cl₂ / 2 h / 0 - 25 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; water; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; <(S,S)-Et-DuP-Rh>(+)TfO(-); In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 234122-64-6
(S)-methyl 2-((benzyloxycarbonyl)amino)-3-(3-hydroxyphenyl)propanoate

: 234122-43-1
(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / H₂ / 10 percent Pd/C / methanol / 12 h / 25 °C

2: 78 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxy-7-azabenzotriazole / CH₂Cl₂ / 3 h / 0 - 25 °C

3: 89 percent / LiOH, H₂O / tetrahydrofuran / 1.5 h / 0 - 25 °C

4: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxy-7-azabenzotriazole, i-Pr₂NEt / CH₂Cl₂ / 3.5 h / 0 - 25 °C

5: TFA / CH₂Cl₂ / 2 h / 0 - 25 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; water; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;