(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)octahydropentalene-3a-carboxylic acid

Base Information

Chemical Name:(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)octahydropentalene-3a-carboxylic acid
CAS No.:1461687-72-8
Molecular Formula:C₂₀H₂₇NO₂
Molecular Weight:313.44
Hs Code.:

Synonyms:(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)octahydropentalene-3a-carboxylic acid

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Chemical Property of (2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)octahydropentalene-3a-carboxylic acid

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)octahydropentalene-3a-carboxylic acid

There total 8 articles about (2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)octahydropentalene-3a-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1461687-68-2
(2R,3aR,6aR)-benzyl 2-(4-phenylpiperidin-1-yl)octahydropentalene-3a-carboxylate

: 1461687-72-8
(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)octahydropentalene-3a-carboxylic acid

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 1h; under 2585.81 Torr;

Reference yield:

: 1461687-61-5
(1R,4S)-benzyl 1-(3-bromopropyl)-4-(2,5-dimethyl-1H-pyrrol-1-yl)cyclopent-2-enecarboxylate

: 1461687-72-8
(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)octahydropentalene-3a-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 4 h / 110 °C

2: sodium hydroxide; hydroxylamine hydrochloride / methanol; water / 8 h / 65 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 120 °C / Microwave irradiation

4: palladium on activated charcoal; hydrogen / methanol / 1 h / 20 °C / 2585.81 Torr

With 2,2'-azobis(isobutyronitrile); palladium on activated charcoal; hydroxylamine hydrochloride; hydrogen; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; water; toluene; acetonitrile;

Reference yield:

: (S)-benzyl 4-(2,5-dimethyl-1H-pyrrol-1-yl)cyclopent-2-enecarboxylate

: 1461687-72-8
(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)octahydropentalene-3a-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -50 °C

1.2: 2 h / -50 - -20 °C

2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 4 h / 110 °C

3.1: sodium hydroxide; hydroxylamine hydrochloride / methanol; water / 8 h / 65 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 120 °C / Microwave irradiation

5.1: palladium on activated charcoal; hydrogen / methanol / 1 h / 20 °C / 2585.81 Torr

With 2,2'-azobis(isobutyronitrile); palladium on activated charcoal; hydroxylamine hydrochloride; hydrogen; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; toluene; acetonitrile;