[(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)hexahydropentalen-3a(1H)-yl]{(1S,4S)-5-[4-(trifluoromethyl)pyridin-2-yl]-2,5-diazabicyclo[2.2.1]hept-2-yl}methanone

Base Information

Chemical Name:[(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)hexahydropentalen-3a(1H)-yl]{(1S,4S)-5-[4-(trifluoromethyl)pyridin-2-yl]-2,5-diazabicyclo[2.2.1]hept-2-yl}methanone
CAS No.:1461687-79-5
Molecular Formula:C₃₁H₃₇F₃N₄O
Molecular Weight:538.656
Hs Code.:

[(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)hexahydropentalen-3a(1H)-yl]{(1S,4S)-5-[4-(trifluoromethyl)pyridin-2-yl]-2,5-diazabicyclo[2.2.1]hept-2-yl}methanone

Synonyms:[(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)hexahydropentalen-3a(1H)-yl]{(1S,4S)-5-[4-(trifluoromethyl)pyridin-2-yl]-2,5-diazabicyclo[2.2.1]hept-2-yl}methanone

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Chemical Property of [(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)hexahydropentalen-3a(1H)-yl]{(1S,4S)-5-[4-(trifluoromethyl)pyridin-2-yl]-2,5-diazabicyclo[2.2.1]hept-2-yl}methanone

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Technology Process of [(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)hexahydropentalen-3a(1H)-yl]{(1S,4S)-5-[4-(trifluoromethyl)pyridin-2-yl]-2,5-diazabicyclo[2.2.1]hept-2-yl}methanone

There total 12 articles about [(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)hexahydropentalen-3a(1H)-yl]{(1S,4S)-5-[4-(trifluoromethyl)pyridin-2-yl]-2,5-diazabicyclo[2.2.1]hept-2-yl}methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1461687-76-2
(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl((2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)octahydropentalen-3a-yl)methanone

: 81565-18-6
2-chloro-4-trifluoromethyl pyridine

: 1461687-79-5
[(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)hexahydropentalen-3a(1H)-yl]{(1S,4S)-5-[4-(trifluoromethyl)pyridin-2-yl]-2,5-diazabicyclo[2.2.1]hept-2-yl}methanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 100 ℃;

Reference yield:

: 1461687-68-2
(2R,3aR,6aR)-benzyl 2-(4-phenylpiperidin-1-yl)octahydropentalene-3a-carboxylate

: 1461687-79-5
[(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)hexahydropentalen-3a(1H)-yl]{(1S,4S)-5-[4-(trifluoromethyl)pyridin-2-yl]-2,5-diazabicyclo[2.2.1]hept-2-yl}methanone

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; palladium on activated charcoal / methanol / 1 h / 20 °C / 2585.81 Torr

2: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0.5 h / 20 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 100 °C

With hydrogenchloride; oxalyl dichloride; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1461687-72-8
(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)octahydropentalene-3a-carboxylic acid

: 1461687-79-5
[(2R,3aR,6aR)-2-(4-phenylpiperidin-1-yl)hexahydropentalen-3a(1H)-yl]{(1S,4S)-5-[4-(trifluoromethyl)pyridin-2-yl]-2,5-diazabicyclo[2.2.1]hept-2-yl}methanone

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0.5 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 100 °C

With hydrogenchloride; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;