4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2'-nitro-5'-trifluoromethyl-biphenyl-2-carboxylic acid

Base Information

Chemical Name:4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2'-nitro-5'-trifluoromethyl-biphenyl-2-carboxylic acid
CAS No.:1428480-62-9
Molecular Formula:C₂₃H₁₁Cl₂F₃N₂O₄S
Molecular Weight:539.319
Hs Code.:

Synonyms:4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2'-nitro-5'-trifluoromethyl-biphenyl-2-carboxylic acid

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Chemical Property of 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2'-nitro-5'-trifluoromethyl-biphenyl-2-carboxylic acid

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Technology Process of 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2'-nitro-5'-trifluoromethyl-biphenyl-2-carboxylic acid

There total 6 articles about 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2'-nitro-5'-trifluoromethyl-biphenyl-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1428482-19-2
C₂₄H₁₃Cl₂F₃N₂O₄S

: 1428480-62-9
4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2'-nitro-5'-trifluoromethyl-biphenyl-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 60 ℃; for 24h;

Reference yield:

: 1428482-14-7
2-bromo-5-thiocarbamoyl-benzoic acid methyl ester

: 1428480-62-9
4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2'-nitro-5'-trifluoromethyl-biphenyl-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 70 °C

2: palladium diacetate; copper(l) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere

3: sodium hydroxide / water; tetrahydrofuran / 24 h / 60 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; caesium carbonate; copper(l) chloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;

Reference yield:

: 1428482-15-8
2-bromo-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid methyl ester

: 1428480-62-9
4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2'-nitro-5'-trifluoromethyl-biphenyl-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; copper(l) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere

2: sodium hydroxide / water; tetrahydrofuran / 24 h / 60 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; caesium carbonate; copper(l) chloride; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;