2-[(phenylmethyl)oxy]-5-(1-piperidinyl)-N-3-pyridinylbenzamide

Base Information

Chemical Name:2-[(phenylmethyl)oxy]-5-(1-piperidinyl)-N-3-pyridinylbenzamide
CAS No.:1285513-87-2
Molecular Formula:C₂₄H₂₅N₃O₂
Molecular Weight:387.481
Hs Code.:

Synonyms:2-[(phenylmethyl)oxy]-5-(1-piperidinyl)-N-3-pyridinylbenzamide

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Chemical Property of 2-[(phenylmethyl)oxy]-5-(1-piperidinyl)-N-3-pyridinylbenzamide

Chemical Property:

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Technology Process of 2-[(phenylmethyl)oxy]-5-(1-piperidinyl)-N-3-pyridinylbenzamide

There total 4 articles about 2-[(phenylmethyl)oxy]-5-(1-piperidinyl)-N-3-pyridinylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[(phenylmethyl)oxy]-5-(1-piperidinyl)-N-3-pyridinylbenzamide trifluoroacetate

: 1285513-87-2
2-[(phenylmethyl)oxy]-5-(1-piperidinyl)-N-3-pyridinylbenzamide

Guidance literature:: With sodium hydrogencarbonate; In water;

Reference yield:

: 89-55-4
5-bromosalicyclic acid

: 1285513-87-2
2-[(phenylmethyl)oxy]-5-(1-piperidinyl)-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 70 °C

2.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 10 h / Inert atmosphere; Reflux

3.1: water; lithium hydroxide / tetrahydrofuran / 12 h / Reflux

3.2: pH 2

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 3 h / 40 °C

5.1: sodium hydrogencarbonate / water

With water; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 850350-09-3
phenylmethyl 5-bromo-2-[(phenylmethyl)oxy]benzoate

: 1285513-87-2
2-[(phenylmethyl)oxy]-5-(1-piperidinyl)-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 10 h / Inert atmosphere; Reflux

2.1: water; lithium hydroxide / tetrahydrofuran / 12 h / Reflux

2.2: pH 2

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 3 h / 40 °C

4.1: sodium hydrogencarbonate / water

With water; sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;