tert-butyl 2-(4-(6-(3-(2-tert-butyl-6-oxo-4H-thieno[2,3-c]pyrrol-5(6H)-yl)-2-methylphenyl)-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-4-methyl-3-oxopiperazine-1-carboxylate

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Chemical Name:tert-butyl 2-(4-(6-(3-(2-tert-butyl-6-oxo-4H-thieno[2,3-c]pyrrol-5(6H)-yl)-2-methylphenyl)-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-4-methyl-3-oxopiperazine-1-carboxylate
CAS No.:1361940-92-2
Molecular Formula:C₃₈H₄₄N₆O₅S
Molecular Weight:696.871
Hs Code.:

tert-butyl 2-(4-(6-(3-(2-tert-butyl-6-oxo-4H-thieno[2,3-c]pyrrol-5(6H)-yl)-2-methylphenyl)-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-4-methyl-3-oxopiperazine-1-carboxylate

Synonyms:tert-butyl 2-(4-(6-(3-(2-tert-butyl-6-oxo-4H-thieno[2,3-c]pyrrol-5(6H)-yl)-2-methylphenyl)-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-4-methyl-3-oxopiperazine-1-carboxylate

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Chemical Property of tert-butyl 2-(4-(6-(3-(2-tert-butyl-6-oxo-4H-thieno[2,3-c]pyrrol-5(6H)-yl)-2-methylphenyl)-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-4-methyl-3-oxopiperazine-1-carboxylate

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Technology Process of tert-butyl 2-(4-(6-(3-(2-tert-butyl-6-oxo-4H-thieno[2,3-c]pyrrol-5(6H)-yl)-2-methylphenyl)-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-4-methyl-3-oxopiperazine-1-carboxylate

There total 11 articles about tert-butyl 2-(4-(6-(3-(2-tert-butyl-6-oxo-4H-thieno[2,3-c]pyrrol-5(6H)-yl)-2-methylphenyl)-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-4-methyl-3-oxopiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1361386-50-6
2-(tert-butyl)-5-[2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4H-thieno[2,3-c]pyrrol-6(5H)-one

: 1361940-91-1
tert-butyl 2-(4-(6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-4-methyl-3-oxopiperazine-1-carboxylate

: 1361940-92-2
tert-butyl 2-(4-(6-(3-(2-tert-butyl-6-oxo-4H-thieno[2,3-c]pyrrol-5(6H)-yl)-2-methylphenyl)-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-4-methyl-3-oxopiperazine-1-carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; for 16.5h; Inert atmosphere; Reflux;

Reference yield:

: 61341-26-2
3-methylthenoyl chloride

: 1361940-92-2
tert-butyl 2-(4-(6-(3-(2-tert-butyl-6-oxo-4H-thieno[2,3-c]pyrrol-5(6H)-yl)-2-methylphenyl)-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-4-methyl-3-oxopiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 18 h / Reflux

2.1: aluminum (III) chloride / dichloromethane / 0.17 h / -78 °C

2.2: 25.75 h / -78 - 20 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 85 °C

4.1: caesium carbonate / acetonitrile / 16 h / 20 °C / Inert atmosphere

5.1: lithium hydroxide / water; tetrahydrofuran; methanol / 16 h / 40 °C

5.2: pH 4

6.1: thionyl chloride / dichloromethane / 16 h / 20 °C / Inert atmosphere

7.1: potassium acetate; XPhos / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; 1,4-dioxane; water / 16.5 h / Inert atmosphere; Reflux

With aluminum (III) chloride; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); potassium acetate; sodium carbonate; caesium carbonate; lithium hydroxide; XPhos; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 4.1: Buchwald reaction;

Reference yield:

: 1361940-88-6
1-methyl-3-(4-nitrophenyl)-5,6-dihydropyrazin-2(1H)-one

: 1361940-92-2
tert-butyl 2-(4-(6-(3-(2-tert-butyl-6-oxo-4H-thieno[2,3-c]pyrrol-5(6H)-yl)-2-methylphenyl)-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-4-methyl-3-oxopiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium cyanoborohydride; zinc(II) chloride / methanol / 1 h / 20 °C / Inert atmosphere

1.2: 18 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 20 °C / 2585.81 Torr / Inert atmosphere

3.1: caesium carbonate / 1,4-dioxane / 0.5 h / Inert atmosphere

3.2: 18 h / Reflux

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; 1,4-dioxane; water / 16.5 h / Inert atmosphere; Reflux

With hydrogen; sodium cyanoborohydride; sodium carbonate; caesium carbonate; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;