2-tert-butyl-5-(2-methyl-3-(4-methyl-6-(4-(4-methyl-3-oxopiperazin-2-yl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)-4H-thieno[2,3-c]pyrrol-6(5H)-one

Base Information

Chemical Name:2-tert-butyl-5-(2-methyl-3-(4-methyl-6-(4-(4-methyl-3-oxopiperazin-2-yl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)-4H-thieno[2,3-c]pyrrol-6(5H)-one
CAS No.:1361940-93-3
Molecular Formula:C₃₃H₃₆N₆O₃S
Molecular Weight:596.753
Hs Code.:

2-tert-butyl-5-(2-methyl-3-(4-methyl-6-(4-(4-methyl-3-oxopiperazin-2-yl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)-4H-thieno[2,3-c]pyrrol-6(5H)-one

Synonyms:2-tert-butyl-5-(2-methyl-3-(4-methyl-6-(4-(4-methyl-3-oxopiperazin-2-yl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)-4H-thieno[2,3-c]pyrrol-6(5H)-one

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Chemical Property of 2-tert-butyl-5-(2-methyl-3-(4-methyl-6-(4-(4-methyl-3-oxopiperazin-2-yl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)-4H-thieno[2,3-c]pyrrol-6(5H)-one

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-tert-butyl-5-(2-methyl-3-(4-methyl-6-(4-(4-methyl-3-oxopiperazin-2-yl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)-4H-thieno[2,3-c]pyrrol-6(5H)-one

There total 11 articles about 2-tert-butyl-5-(2-methyl-3-(4-methyl-6-(4-(4-methyl-3-oxopiperazin-2-yl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)-4H-thieno[2,3-c]pyrrol-6(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1361940-92-2
tert-butyl 2-(4-(6-(3-(2-tert-butyl-6-oxo-4H-thieno[2,3-c]pyrrol-5(6H)-yl)-2-methylphenyl)-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-4-methyl-3-oxopiperazine-1-carboxylate

: 1361940-93-3
2-tert-butyl-5-(2-methyl-3-(4-methyl-6-(4-(4-methyl-3-oxopiperazin-2-yl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)-4H-thieno[2,3-c]pyrrol-6(5H)-one

Guidance literature:: tert-butyl 2-(4-(6-(3-(2-tert-butyl-6-oxo-4H-thieno[2,3-c]pyrrol-5(6H)-yl)-2-methylphenyl)-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)-4-methyl-3-oxopiperazine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; methanol; water; ethyl acetate; for 2h; Inert atmosphere;

With potassium carbonate; In 1,4-dioxane; methanol; water; ethyl acetate; pH=6.5;

Reference yield:

: 61341-26-2
3-methylthenoyl chloride

: 1361940-93-3
2-tert-butyl-5-(2-methyl-3-(4-methyl-6-(4-(4-methyl-3-oxopiperazin-2-yl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)-4H-thieno[2,3-c]pyrrol-6(5H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: 18 h / Reflux

2.1: aluminum (III) chloride / dichloromethane / 0.17 h / -78 °C

2.2: 25.75 h / -78 - 20 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 85 °C

4.1: caesium carbonate / acetonitrile / 16 h / 20 °C / Inert atmosphere

5.1: lithium hydroxide / water; tetrahydrofuran; methanol / 16 h / 40 °C

5.2: pH 4

6.1: thionyl chloride / dichloromethane / 16 h / 20 °C / Inert atmosphere

7.1: potassium acetate; XPhos / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; 1,4-dioxane; water / 16.5 h / Inert atmosphere; Reflux

9.1: hydrogenchloride / ethyl acetate; 1,4-dioxane; water; methanol / 2 h / Inert atmosphere

9.2: pH 6.5

With hydrogenchloride; aluminum (III) chloride; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); potassium acetate; sodium carbonate; caesium carbonate; lithium hydroxide; XPhos; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 4.1: Buchwald reaction;

Reference yield:

: 1361940-88-6
1-methyl-3-(4-nitrophenyl)-5,6-dihydropyrazin-2(1H)-one

: 1361940-93-3
2-tert-butyl-5-(2-methyl-3-(4-methyl-6-(4-(4-methyl-3-oxopiperazin-2-yl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)-4H-thieno[2,3-c]pyrrol-6(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium cyanoborohydride; zinc(II) chloride / methanol / 1 h / 20 °C / Inert atmosphere

1.2: 18 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 20 °C / 2585.81 Torr / Inert atmosphere

3.1: caesium carbonate / 1,4-dioxane / 0.5 h / Inert atmosphere

3.2: 18 h / Reflux

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; 1,4-dioxane; water / 16.5 h / Inert atmosphere; Reflux

5.1: hydrogenchloride / ethyl acetate; 1,4-dioxane; water; methanol / 2 h / Inert atmosphere

5.2: pH 6.5

With hydrogenchloride; hydrogen; sodium cyanoborohydride; sodium carbonate; caesium carbonate; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;