ethyl 5-amino-3-(4-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate

Base Information

Chemical Name:ethyl 5-amino-3-(4-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate
CAS No.:433233-28-4
Molecular Formula:C₁₅H₁₂FN₃O₃S
Molecular Weight:333.343
Hs Code.:

Synonyms:ethyl 5-amino-3-(4-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate

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Chemical Property of ethyl 5-amino-3-(4-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate

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Technology Process of ethyl 5-amino-3-(4-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate

There total 4 articles about ethyl 5-amino-3-(4-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 443666-61-3
ethyl 5-cyano-1-(4-fluorophenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate

: 433233-28-4
ethyl 5-amino-3-(4-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate

Guidance literature:: With morpholine; sulfur; In ethanol; at 150 ℃; for 0.25h; Inert atmosphere; Microwave irradiation;
DOI:10.1039/c6md00306k

Reference yield:

: 371-40-4
4-fluoroaniline

: 433233-28-4
ethyl 5-amino-3-(4-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / ethanol; water / 0 °C

1.2: 4 h / 0 °C

2.1: sodium acetate; acetic acid / 0.07 h / 170 °C / Microwave irradiation

3.1: morpholine; sulfur / ethanol / 0.25 h / 150 °C / Microwave irradiation

With morpholine; hydrogenchloride; sulfur; sodium acetate; acetic acid; sodium nitrite; In ethanol; water; 3.1: Gewald reaction;
DOI:10.1016/j.bmc.2012.05.027

Reference yield:

: 66053-11-0
ethyl 2-(2-(4-fluorophenyl)hydrazono)-3-oxobutanoate

: 433233-28-4
ethyl 5-amino-3-(4-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate; acetic acid / 0.07 h / 170 °C / Microwave irradiation

2: morpholine; sulfur / ethanol / 0.25 h / 150 °C / Microwave irradiation

With morpholine; sulfur; sodium acetate; acetic acid; In ethanol; 2: Gewald reaction;
DOI:10.1016/j.bmc.2012.05.027