[4-({(S)-2-[(R)-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionylamino]-3-phenyl-propionylamino}-methyl)-benzyl]-carbamic acid tert-butyl ester

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Chemical Name:[4-({(S)-2-[(R)-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionylamino]-3-phenyl-propionylamino}-methyl)-benzyl]-carbamic acid tert-butyl ester
CAS No.:1417693-99-2
Molecular Formula:C₃₄H₄₄N₄O₇S
Molecular Weight:652.812
Hs Code.:

Synonyms:[4-({(S)-2-[(R)-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionylamino]-3-phenyl-propionylamino}-methyl)-benzyl]-carbamic acid tert-butyl ester

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Chemical Property of [4-({(S)-2-[(R)-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionylamino]-3-phenyl-propionylamino}-methyl)-benzyl]-carbamic acid tert-butyl ester

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Technology Process of [4-({(S)-2-[(R)-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionylamino]-3-phenyl-propionylamino}-methyl)-benzyl]-carbamic acid tert-butyl ester

There total 7 articles about [4-({(S)-2-[(R)-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionylamino]-3-phenyl-propionylamino}-methyl)-benzyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1417693-98-1
(R)-N-[(S)-1-(4-cyano-benzylcarbamoyl)-2-phenyl-ethyl]-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionamide

: 1417693-99-2
[4-({(S)-2-[(R)-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionylamino]-3-phenyl-propionylamino}-methyl)-benzyl]-carbamic acid tert-butyl ester

Guidance literature:: With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at 0 - 20 ℃; for 18h;

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 1417693-99-2
[4-({(S)-2-[(R)-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionylamino]-3-phenyl-propionylamino}-methyl)-benzyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole / dichloromethane; N,N-dimethyl-formamide / 18 h / 0 - 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 18 h / 20 °C

3: benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole / dichloromethane; N,N-dimethyl-formamide / 18 h / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5: triethylamine / dichloromethane / 18 h / 0 - 20 °C

6: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; nickel(II) chloride hexahydrate; lithium hydroxide monohydrate; benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 76757-92-1,247088-44-4
(R)-2-((tert-butoxycarbonyl)amino)-3-(4-ethoxyphenyl)propanoic acid

: 1417693-99-2
[4-({(S)-2-[(R)-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionylamino]-3-phenyl-propionylamino}-methyl)-benzyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole / dichloromethane; N,N-dimethyl-formamide / 18 h / 0 - 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 18 h / 20 °C

3: benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole / dichloromethane; N,N-dimethyl-formamide / 18 h / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5: triethylamine / dichloromethane / 18 h / 0 - 20 °C

6: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; nickel(II) chloride hexahydrate; lithium hydroxide monohydrate; benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;