(R)-N-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethyl]-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionamide trifluoroacetate

Base Information

Chemical Name:(R)-N-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethyl]-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionamide trifluoroacetate
CAS No.:1417694-01-9
Molecular Formula:C₂HF₃O₂*C₂₉H₃₆N₄O₅S
Molecular Weight:666.719
Hs Code.:

Synonyms:(R)-N-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethyl]-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionamide trifluoroacetate

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Chemical Property of (R)-N-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethyl]-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionamide trifluoroacetate

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Technology Process of (R)-N-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethyl]-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionamide trifluoroacetate

There total 7 articles about (R)-N-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethyl]-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1417693-99-2
[4-({(S)-2-[(R)-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionylamino]-3-phenyl-propionylamino}-methyl)-benzyl]-carbamic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 1417694-01-9
(R)-N-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethyl]-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionamide trifluoroacetate

Guidance literature:: at 20 ℃; for 1h;

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 1417694-01-9
(R)-N-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethyl]-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole / dichloromethane; N,N-dimethyl-formamide / 18 h / 0 - 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 18 h / 20 °C

3: benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole / dichloromethane; N,N-dimethyl-formamide / 18 h / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5: triethylamine / dichloromethane / 18 h / 0 - 20 °C

6: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C

7: 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; nickel(II) chloride hexahydrate; lithium hydroxide monohydrate; benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 76757-92-1,247088-44-4
(R)-2-((tert-butoxycarbonyl)amino)-3-(4-ethoxyphenyl)propanoic acid

: 1417694-01-9
(R)-N-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethyl]-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole / dichloromethane; N,N-dimethyl-formamide / 18 h / 0 - 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 18 h / 20 °C

3: benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole / dichloromethane; N,N-dimethyl-formamide / 18 h / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5: triethylamine / dichloromethane / 18 h / 0 - 20 °C

6: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C

7: 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; nickel(II) chloride hexahydrate; lithium hydroxide monohydrate; benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;