tert-butyl 2-((5-(((allyloxycarbonyl)-((S)-3,3-dimethyl-butan-2-yl)amino)methyl)-2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 2-((5-(((allyloxycarbonyl)-((S)-3,3-dimethyl-butan-2-yl)amino)methyl)-2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)pyrrolidine-1-carboxylate
CAS No.:1575819-84-9
Molecular Formula:C₂₈H₄₃N₅O₄
Molecular Weight:513.681
Hs Code.:

tert-butyl 2-((5-(((allyloxycarbonyl)-((S)-3,3-dimethyl-butan-2-yl)amino)methyl)-2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)pyrrolidine-1-carboxylate

Synonyms:tert-butyl 2-((5-(((allyloxycarbonyl)-((S)-3,3-dimethyl-butan-2-yl)amino)methyl)-2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl 2-((5-(((allyloxycarbonyl)-((S)-3,3-dimethyl-butan-2-yl)amino)methyl)-2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl 2-((5-(((allyloxycarbonyl)-((S)-3,3-dimethyl-butan-2-yl)amino)methyl)-2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)pyrrolidine-1-carboxylate

There total 1 articles about tert-butyl 2-((5-(((allyloxycarbonyl)-((S)-3,3-dimethyl-butan-2-yl)amino)methyl)-2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 1575819-84-9
tert-butyl 2-((5-(((allyloxycarbonyl)-((S)-3,3-dimethyl-butan-2-yl)amino)methyl)-2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

3: sodium carbonate / water / 24 h / 0 - 20 °C

4: zinc; ammonium chloride / methanol / 1 h / 50 °C

5: ethanol / 3 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; sodium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In methanol; ethanol; water; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 1575819-84-9
tert-butyl 2-((5-(((allyloxycarbonyl)-((S)-3,3-dimethyl-butan-2-yl)amino)methyl)-2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)pyrrolidine-1-carboxylate

: 1575819-88-3
allyl (2-(4-chlorobenzamido)-1-((1-(2-cyanoacetyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl-((S)-3,3-dimethylbutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: dichloromethane / 7 h / 0 - 20 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1575819-84-9
tert-butyl 2-((5-(((allyloxycarbonyl)-((S)-3,3-dimethyl-butan-2-yl)amino)methyl)-2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)pyrrolidine-1-carboxylate

: 1575819-89-4
allyl (2-(4-chlorobenzamido)-1-((1-(2-cyano-4-(dimethylamino)-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl-((S)-3,3-dimethylbutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: dichloromethane / 7 h / 0 - 20 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

4: piperidine / 12 h / 90 °C / Sealed tube

With piperidine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;