PIPERIDINE, 4-[(4-METHYLPHENYL)METHYL]-, HYDROCHLORIDE

Base Information

• Chemical Name: PIPERIDINE, 4-[(4-METHYLPHENYL)METHYL]-, HYDROCHLORIDE
• CAS No.: 165110-20-3
• Molecular Formula: C₁₃H₁₉N*ClH
• Molecular Weight: 225.762
• Hs Code.: 2933399090
• Mol file: 165110-20-3.mol

Synonyms:Piperidine,4-[(4-methylphenyl)methyl]-, hydrochloride (9CI)

Chemical Property of PIPERIDINE, 4-[(4-METHYLPHENYL)METHYL]-, HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.00124mmHg at 25°C
• Boiling Point: 298.9°C at 760 mmHg
• Flash Point: 137.5°C
• PSA: 12.03000
• LogP: 3.66790

Purity/Quality:

98%Min ^*data from raw suppliers

4-(4-Methylbenzyl)piperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(4-Methylbenzyl)piperidine Hydrochloride is used in preparation of amino amide derivatives as LpxC enzyme inhibitor and antibacterial agents.

Technology Process of PIPERIDINE, 4-[(4-METHYLPHENYL)METHYL]-, HYDROCHLORIDE

There total 10 articles about PIPERIDINE, 4-[(4-METHYLPHENYL)METHYL]-, HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-benzyl-4-(4-methylbenzyl)piperidine hydrochloride → 4-[(4-methylphenyl)methyl]piperidine hydrochloride (165110-20-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 12h; under 3102.89 Torr;

DOI:10.1021/jm990246i

Reference yield: 97.0%

(4-methylphenyl)(pyridin-4-yl)methanone (14548-30-2) → 4-[(4-methylphenyl)methyl]piperidine hydrochloride (165110-20-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; 1,2-dichloro-ethane; at 45 ℃; for 4.2h; chemoselective reaction;

DOI:10.1016/j.tet.2013.12.017

Reference yield: 89.0%

α-(4-methylphenyl)-4-pyridinemethanol (33974-28-6) → 4-[(4-methylphenyl)methyl]piperidine hydrochloride (165110-20-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; at 60 ℃; under 750.075 Torr;

DOI:10.1002/ejoc.200400215

upstream raw materials:

(4-methylphenyl)(pyridin-4-yl)methanone

α-(4-methylphenyl)-4-pyridinemethanol

pyridine-4-carbaldehyde

para-methylphenylmagnesium bromide

Downstream raw materials:

1-[2-(4-Hydroxy-3-methylphenoxy)ethyl]-4-(4-methylbenzyl)piperidine hydrochloride

Refernces

• 1、 -. "GLYCOSIDASE INHIBITORS". Page/Page column 100. . Retrieved 2014/10/15.
• 2、 -. "4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists". . . Retrieved 2011/05/18.