(4-Methylphenyl)(4-pyridinyl)methanol

Base Information

• Chemical Name: (4-Methylphenyl)(4-pyridinyl)methanol
• CAS No.: 33974-28-6
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• ChEMBL ID: CHEMBL1867285
• Mol file: 33974-28-6.mol

Synonyms:(4-methylphenyl)(4-pyridinyl)methanol;(4-methylphenyl)-pyridin-4-ylmethanol;33974-28-6;4-Pyridinemethanol, alpha-(4-methylphenyl)-;SMR000160413;MLS000537100;SCHEMBL8737044;CHEMBL1867285;HMS2453I22;AMY41539;a-(4-methylphenyl)-4-pyridinemethanol;|A-(4-methylphenyl)-4-pyridinemethanol;AM-814/41092120

Chemical Property of (4-Methylphenyl)(4-pyridinyl)methanol

Chemical Property:

• PSA: 33.12000
• LogP: 2.47170
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 199.099714038
• Heavy Atom Count: 15
• Complexity: 181

Purity/Quality:

97% purity ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(C2=CC=NC=C2)O

Technology Process of (4-Methylphenyl)(4-pyridinyl)methanol

There total 5 articles about (4-Methylphenyl)(4-pyridinyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

pyridine-4-carbonitrile (100-48-1) + 4-methyl-benzaldehyde (104-87-0) → α-(4-methylphenyl)-4-pyridinemethanol (33974-28-6)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; tetrabutylammonium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Sealed tube; Electrochemical reaction;

DOI:10.1021/acs.orglett.1c00920

Reference yield: 74.0%

pyridine-4-carbaldehyde (872-85-5) + para-methylphenylmagnesium bromide (4294-57-9) → α-(4-methylphenyl)-4-pyridinemethanol (33974-28-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 10h;

DOI:10.1002/ejoc.200400215

Reference yield: 35.0%

4-methyl-benzaldehyde (104-87-0) + triphenyl(pyridin-4-yl)phosphonium trifluoromethanesulfonate (113964-72-0) → 4,4'-bipyridine (553-26-4) + α-(4-methylphenyl)-4-pyridinemethanol (33974-28-6)

Guidance literature:

With cesium fluoride; In various solvent(s); 1.) 80 deg C, 2 h; 2.) 100 deg C, 12 h;

upstream raw materials:

pyridine-4-carbaldehyde

para-bromotoluene

4-methyl-benzaldehyde

triphenyl(pyridin-4-yl)phosphonium trifluoromethanesulfonate

Downstream raw materials:

1-Methyl-4-(4-methyl-benzyl)-1,2,3,6-tetrahydro-pyridine

4-(4-methylbenzyl)-1-but-3-ynylpiperidine

4-[(4methylphenyl)methyl]piperidine

4-[(4-methylphenyl)methyl]piperidine hydrochloride