1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidamide

Base Information

Chemical Name:1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidamide
CAS No.:1446712-60-2
Molecular Formula:C₁₄H₁₂F₂N₆
Molecular Weight:302.286
Hs Code.:

Synonyms:1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidamide

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Chemical Property of 1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidamide

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Technology Process of 1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidamide

There total 5 articles about 1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1446712-59-9
1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile

: 1446712-60-2
1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidamide

Guidance literature:: 1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile; With sodium methylate; In methanol; at 20 ℃; for 1h; Inert atmosphere;

With ammonium chloride; acetic acid; In methanesulfonic acid; for 2h; Inert atmosphere; Reflux;

Reference yield:

: 1446712-58-8
1-(2,3-difluorobenzyl)-3-iodo-6-methyl-1H-pyrazolo[3,4-d]pyrimidine

: 1446712-60-2
1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethyl sulfoxide / 2 h / 150 °C

2.1: sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere; Reflux

With sodium methylate; In methanol; dimethyl sulfoxide;

Reference yield:

: 1276056-73-5
6-methyl-1H-pyrazolo[3,4-d]pyrimidine

: 1446712-60-2
1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 80 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice

3.1: dimethyl sulfoxide / 2 h / 150 °C

4.1: sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

4.2: 2 h / Inert atmosphere; Reflux

With N-iodo-succinimide; sodium methylate; caesium carbonate; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;