methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-hydroxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

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Chemical Name:methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-hydroxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate
CAS No.:96898-28-1
Molecular Formula:C₃₂H₂₈N₄O₈
Molecular Weight:596.596
Hs Code.:

Synonyms:methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-hydroxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

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Chemical Property of methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-hydroxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

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Technology Process of methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-hydroxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

There total 3 articles about methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-hydroxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83220-14-8
dimethyl 4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2,5-dicarboxylate

: 96898-28-1
methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-hydroxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: NaSePh / tetrahydrofuran; hexamethylphosphoric acid triamide / 21 h / 70 °C

2: HCl (10percent) / 18 h / 25 °C

3: 1.) (PhO)2P(O)N₃, Et₃N / 1.) C₆H₆, 80 deg C, 2.5 h; 2.) H₂O-C₆H₆, 80 deg C, 1 h

With hydrogenchloride; diphenyl phosphoryl azide; sodium phenylselenide; triethylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/ja00306a024

Reference yield:

: 96898-27-0
4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-hydroxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid 2-methyl ester

: 96898-28-1
methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-hydroxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; Yield given. Multistep reaction; 1.) C₆H₆, 80 deg C, 2.5 h; 2.) H₂O-C₆H₆, 80 deg C, 1 h;
DOI:10.1021/ja00306a024

Reference yield:

: 96898-26-9
4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-hydroxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid

: 96898-28-1
methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-hydroxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: HCl (10percent) / 18 h / 25 °C

2: 1.) (PhO)2P(O)N₃, Et₃N / 1.) C₆H₆, 80 deg C, 2.5 h; 2.) H₂O-C₆H₆, 80 deg C, 1 h

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine;
DOI:10.1021/ja00306a024