4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-hydroxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid 2-methyl ester

Base Information

Chemical Name:4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-hydroxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid 2-methyl ester
CAS No.:96898-27-0
Molecular Formula:C₃₃H₂₇N₃O₁₀
Molecular Weight:625.591
Hs Code.:

Synonyms:4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-hydroxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid 2-methyl ester

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Chemical Property of 4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-hydroxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid 2-methyl ester

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Technology Process of 4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-hydroxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid 2-methyl ester

There total 2 articles about 4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-hydroxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83220-14-8
dimethyl 4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2,5-dicarboxylate

: 96898-27-0
4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-hydroxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid 2-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaSePh / tetrahydrofuran; hexamethylphosphoric acid triamide / 21 h / 70 °C

2: HCl (10percent) / 18 h / 25 °C

With hydrogenchloride; sodium phenylselenide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/ja00306a024

Reference yield:

: 67-56-1
methanol

: 96898-26-9
4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-hydroxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid

: 96898-27-0
4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-hydroxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid 2-methyl ester

Guidance literature:: With hydrogenchloride; at 25 ℃; for 18h;
DOI:10.1021/ja00306a024

Reference yield:

: 96898-27-0
4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-hydroxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid 2-methyl ester

: 77405-78-8
methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) (PhO)2P(O)N₃, Et₃N / 1.) C₆H₆, 80 deg C, 2.5 h; 2.) H₂O-C₆H₆, 80 deg C, 1 h

2: 94 percent / K₂CO₃ / tetrahydrofuran / 21 h / 65 °C

With diphenyl phosphoryl azide; potassium carbonate; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja00306a024