methyl-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(tetrahydro-pyran-4-yl)-amine

Base Information

Chemical Name:methyl-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(tetrahydro-pyran-4-yl)-amine
CAS No.:1313733-12-8
Molecular Formula:C₂₁H₂₃F₃N₆O₃
Molecular Weight:464.447
Hs Code.:

methyl-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(tetrahydro-pyran-4-yl)-amine

Synonyms:methyl-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(tetrahydro-pyran-4-yl)-amine

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Chemical Property of methyl-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(tetrahydro-pyran-4-yl)-amine

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Technology Process of methyl-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(tetrahydro-pyran-4-yl)-amine

There total 5 articles about methyl-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(tetrahydro-pyran-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313732-28-3
[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(tetrahydro-pyran-4-yl)-amine

: 74-88-4
methyl iodide

: 1313733-12-8
methyl-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(tetrahydro-pyran-4-yl)-amine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 66643-51-4
3,4-dichloro-5-<(2-hydroxyethyl)methylamino>-pyridazine

: 1313733-12-8
methyl-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(tetrahydro-pyran-4-yl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / tetrahydrofuran / Reflux

2: NCS / acetonitrile / 3 h / 50 °C

3: butan-1-ol / 1.5 h / 185 °C / Microwave irradiation

4: butan-1-ol / 180 - 185 °C / Microwave irradiation

5: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

With potassium tert-butylate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;

Reference yield:

: 66643-52-5
8-chloro-3,4-dihydro-4-methyl-2H-pyridazino<4,5-b>-1,4-oxazine

: 1313733-12-8
methyl-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(tetrahydro-pyran-4-yl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1: NCS / acetonitrile / 3 h / 50 °C

2: butan-1-ol / 1.5 h / 185 °C / Microwave irradiation

3: butan-1-ol / 180 - 185 °C / Microwave irradiation

4: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

With sodium hydride; In N,N-dimethyl-formamide; acetonitrile; butan-1-ol;