methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-1-octenyl]-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]-heptanoate

Base Information

Chemical Name:methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-1-octenyl]-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]-heptanoate
CAS No.:351194-38-2
Molecular Formula:C₃₆H₅₀O₆
Molecular Weight:578.789
Hs Code.:

Synonyms:methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-1-octenyl]-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]-heptanoate

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Chemical Property of methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-1-octenyl]-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]-heptanoate

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Technology Process of methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-1-octenyl]-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]-heptanoate

There total 6 articles about methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-1-octenyl]-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]-heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 351194-35-9
methyl 7-[(1R,2R,3R)-3-(acetyloxy)-2-[(E,3S)-3-(acetyloxy)-1-octenyl]-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]-heptanoate

: 351194-38-2
methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-1-octenyl]-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]-heptanoate

Guidance literature:: With potassium carbonate; In methanol; for 18h;
DOI:10.1021/ja015900+

Reference yield:

: 351194-33-7
methyl 7-[(1R,2R,3R)-3-(acetyloxy)-2-[(1S,2E)-1-(acetyloxy)-2-octenyl]-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]-heptanoate

: 351194-38-2
methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-1-octenyl]-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]-heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / Pd(CH₃CN)2Cl₂ / tetrahydrofuran / 3 h

2: 90 percent / K₂CO₃ / methanol / 18 h

With dichloro bis(acetonitrile) palladium(II); potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1021/ja015900+

Reference yield:

: 351194-27-9
methyl 7-[(1R,2R,3R)-2-[(Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl]-3-hydroxy-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate

: 351194-38-2
methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-1-octenyl]-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]-heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1: Bu₄NF / tetrahydrofuran; dimethylsulfoxide; various solvent(s) / 0.33 h / 80 °C

2: DMAP; pyridine / 0.33 h

3: 63 percent / Pd(CH₃CN)2Cl₂ / tetrahydrofuran / 3 h

4: 90 percent / K₂CO₃ / methanol / 18 h

With pyridine; dmap; dichloro bis(acetonitrile) palladium(II); tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1021/ja015900+