methyl 7-[(1R,2R,3R)-2-[(Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl]-3-hydroxy-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate

Base Information

• Chemical Name: methyl 7-[(1R,2R,3R)-2-[(Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl]-3-hydroxy-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate
• CAS No.: 351194-27-9
• Molecular Formula: C₄₄H₆₀O₆Si
• Molecular Weight: 713.042
• Mol file: 351194-27-9.mol

Synonyms:methyl 7-[(1R,2R,3R)-2-[(Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl]-3-hydroxy-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate

Chemical Property of methyl 7-[(1R,2R,3R)-2-[(Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl]-3-hydroxy-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 7-[(1R,2R,3R)-2-[(Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl]-3-hydroxy-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate

There total 2 articles about methyl 7-[(1R,2R,3R)-2-[(Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl]-3-hydroxy-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

methyl 7-[(1R,2S)-2-{(1R,2Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl}-3-oxo-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate (351194-24-6) → methyl 7-[(1R,2R,3R)-2-[(Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl]-3-hydroxy-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate (351194-27-9)

Guidance literature:

With zinc(II) tetrahydroborate; In diethyl ether; at -30 ℃; for 3h;

DOI:10.1021/ja015900+

Reference yield:

methyl 7-[2-[3-[dimethyl(phenyl)silyl]-1-hydroxy-(2Z)-octenyl]-3-oxo-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate → methyl 7-[(1R,2R,3R)-2-[(Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl]-3-hydroxy-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate (351194-27-9) + methyl 7-[(1S,2S,3R)-2-[(Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl]-3-hydroxy-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate + methyl 7-[2-[(Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl]-3-hydroxy-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate + methyl 7-[2-[(Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl]-3-hydroxy-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate

Guidance literature:

With zinc(II) tetrahydroborate; In diethyl ether; at -30 ℃; for 3h; Further byproducts. Title compound not separated from byproducts.;

DOI:10.1021/jo025987x

Reference yield:

methyl 7-[(1R,2R,3R)-2-[(Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl]-3-hydroxy-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate (351194-27-9) → 7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(S)-1-hydroxy-oct-2-enyl)-8,8-diphenyl-6,10-dioxa-spiro[4.5]dec-1-yl]-heptanoic acid methyl ester (351194-30-4)

Guidance literature:

With propanoic acid methyl ester; tetrabutyl ammonium fluoride; In tetrahydrofuran; dimethyl sulfoxide; for 0.333333h; Heating;

DOI:10.1021/jo025987x

upstream raw materials:

methyl 7-[(1R,2S)-2-{(1R,2Z)-3-[dimethyl(phenyl)silyl]-1-hydroxy-2-octenyl}-3-oxo-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]heptanoate

Downstream raw materials:

7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(S)-1-hydroxy-oct-2-enyl)-8,8-diphenyl-6,10-dioxa-spiro[4.5]dec-1-yl]-heptanoic acid methyl ester

prostaglandin E₁ methyl ester

methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-1-octenyl]-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]-heptanoate

methyl 7-[(1R,2R,3R)-3-(acetyloxy)-2-[(E,3S)-3-(acetyloxy)-1-octenyl]-8,8-diphenyl-6,10-dioxaspiro[4.5]dec-1-yl]-heptanoate