2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-methoxy-5-nitro-quinoline

Base Information

Chemical Name:2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-methoxy-5-nitro-quinoline
CAS No.:77405-73-3
Molecular Formula:C₃₄H₃₁N₃O₆
Molecular Weight:577.637
Hs Code.:

Synonyms:2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-methoxy-5-nitro-quinoline

Suppliers and Price of 2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-methoxy-5-nitro-quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-methoxy-5-nitro-quinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-methoxy-5-nitro-quinoline

There total 13 articles about 2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-methoxy-5-nitro-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 77405-73-3
2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-methoxy-5-nitro-quinoline

Guidance literature:: Multi-step reaction with 7 steps

1: K₂CO₃, KI / dimethylformamide / 14 h / Ambient temperature

2: benzene / 14 h / Heating

3: Na₂S / methanol / 2 h / Heating

4: 96 percent / t-BuOK / toluene; 2-methyl-propan-2-ol / 10 h / Heating

5: 85 percent / TFA / 1 h / 0 °C

6: HNO₃ / nitromethane / 0.42 h / 5 - 20 °C

7: K₂CO₃ / acetone / 5 h / Heating

With sodium sulfide; potassium tert-butylate; nitric acid; potassium carbonate; trifluoroacetic acid; potassium iodide; In methanol; nitromethane; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol; benzene;
DOI:10.1021/ja00395a071

Reference yield:

: 92541-05-4
(Z)-3-Amino-1-(2-benzyloxy-3,4-dimethoxy-phenyl)-2-methyl-but-2-en-1-one

: 77405-73-3
2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-methoxy-5-nitro-quinoline

Guidance literature:: Multi-step reaction with 9 steps

1: 97 percent / xylene / 14 h / Heating

2: NaBH₄ / tetrahydrofuran; propan-2-ol / 16 h / Ambient temperature

3: 67 percent / PhPOCl₂ / 3 h / 170 °C

4: 85 percent / dimethylformamide / 14 h / Heating

5: 2.) H₂O, H⁽¹⁺⁾ / 1) C₆H₆, room temperature, 1.5 h

6: 96 percent / t-BuOK / toluene; 2-methyl-propan-2-ol / 10 h / Heating

7: 85 percent / TFA / 1 h / 0 °C

8: HNO₃ / nitromethane / 0.42 h / 5 - 20 °C

9: K₂CO₃ / acetone / 5 h / Heating

With P,P-dichlorophenylphosphine oxide; sodium tetrahydroborate; potassium tert-butylate; water; nitric acid; hydrogen cation; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; nitromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; toluene; xylene; tert-butyl alcohol;
DOI:10.1021/ja00395a071

Reference yield:

: 77418-04-3
4-(4-Methoxy-benzyloxy)-2-[(E)-p-tolylimino-methyl]-phenylamine

: 77405-73-3
2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-methoxy-5-nitro-quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / t-BuOK / toluene; 2-methyl-propan-2-ol / 10 h / Heating

2: 85 percent / TFA / 1 h / 0 °C

3: HNO₃ / nitromethane / 0.42 h / 5 - 20 °C

4: K₂CO₃ / acetone / 5 h / Heating

With potassium tert-butylate; nitric acid; potassium carbonate; trifluoroacetic acid; In nitromethane; acetone; toluene; tert-butyl alcohol;
DOI:10.1021/ja00395a071