2-Azetidinecarboxylicacid,3-methyl-4-oxo-,methylester,(2S-cis)-(9CI)

Base Information

Chemical Name:2-Azetidinecarboxylicacid,3-methyl-4-oxo-,methylester,(2S-cis)-(9CI)
CAS No.:165036-27-1
Molecular Formula:C₆H₉NO₃
Molecular Weight:143.142
Hs Code.:
Mol file:165036-27-1.mol

Synonyms:2-Azetidinecarboxylicacid,3-methyl-4-oxo-,methylester,(2S-cis)-(9CI)

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Chemical Property of 2-Azetidinecarboxylicacid,3-methyl-4-oxo-,methylester,(2S-cis)-(9CI)

Chemical Property:

Boiling Point:288.1±33.0 °C(Predicted)
PKA:13.84±0.60(Predicted)
PSA：55.40000
Density:1.181±0.06 g/cm3(Predicted)
LogP:-0.37730

Purity/Quality:

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Technology Process of 2-Azetidinecarboxylicacid,3-methyl-4-oxo-,methylester,(2S-cis)-(9CI)

There total 2 articles about 2-Azetidinecarboxylicacid,3-methyl-4-oxo-,methylester,(2S-cis)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 221664-98-8
(3S,4S)-3-methyl-4-(methoxycarbonyl)-1-(4-methoxyphenyl)azetidin-2-one

: 165036-27-1
(2S,3S)-3-Methyl-4-oxo-azetidine-2-carboxylic acid methyl ester

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile; at -10 ℃; for 0.5h;
DOI:10.1021/jo981574d

Reference yield:

: 221664-97-7
(3S,4S)-4-tert-butoxycarbonyl-3-methyl-1-(4-methoxyphenyl)azetidin-2-one

: 165036-27-1
(2S,3S)-3-Methyl-4-oxo-azetidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) trifluoroacetic acid / 1.) CH₂Cl₂, room temperature, 4 h, 2.) diethyl ether, 0 deg C

2: (NH₄)2Ce(NO₃)6 / H₂O; acetonitrile / 0.5 h / -10 °C

With ammonium cerium(IV) nitrate; trifluoroacetic acid; In water; acetonitrile;
DOI:10.1021/jo981574d

Reference yield:

: 165036-27-1
(2S,3S)-3-Methyl-4-oxo-azetidine-2-carboxylic acid methyl ester

: (3S,4S,5S)-3-<(tert-Butoxycarbonyl)amino>-5-(p-methoxyphenyl)-4-methyltetrahydrofuranone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.46 g / 4-(dimethylamino)pyridine / acetonitrile / 16 h

2: 75 percent / tetrahydrofuran / -40 °C

3: L-Selectride / tetrahydrofuran / 1 h / -78 °C

With dmap; L-Selectride; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo981574d