(S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]heptanamide

Base Information

• Chemical Name: (S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]heptanamide
• CAS No.: 1497427-34-5
• Molecular Formula: C₂₁H₃₀FN₃O₄
• Molecular Weight: 407.485
• Mol file: 1497427-34-5.mol

Synonyms:(S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]heptanamide

Chemical Property of (S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]heptanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]heptanamide

There total 4 articles about (S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]heptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Heptanoic acid chloride (2528-61-2) + (S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine (168828-90-8) → (S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]heptanamide (1497427-34-5)

Guidance literature:

With triethylamine; In toluene; at 0 - 20 ℃; for 3h;

DOI:10.13005/ojc/290322

Reference yield:

3-fluoro-4-(morpholinyl)aniline (93246-53-8) → (S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]heptanamide (1497427-34-5)

Guidance literature:

Multi-step reaction with 5 steps

1: methanol / 16 h / Reflux

2: dichloromethane / 20 h / 20 °C

3: N,N-dimethyl-formamide / 5 h / Reflux

4: hydrazine hydrate / methanol / 1 h / Reflux

5: triethylamine / toluene / 3 h / 0 - 20 °C

With hydrazine hydrate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.13005/ojc/290322

Reference yield:

(5R)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone → (S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]heptanamide (1497427-34-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 5 h / Reflux

2: hydrazine hydrate / methanol / 1 h / Reflux

3: triethylamine / toluene / 3 h / 0 - 20 °C

With hydrazine hydrate; triethylamine; In methanol; N,N-dimethyl-formamide; toluene;

DOI:10.13005/ojc/290322

upstream raw materials:

Heptanoic acid chloride

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

N-[3-chloro-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholin-4-yl)aniline

3-fluoro-4-(morpholinyl)aniline