1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-2,2,2-trifluoroethanol

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Chemical Name:1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-2,2,2-trifluoroethanol
CAS No.:1253577-57-9
Molecular Formula:C₃₃H₃₁F₄N₇O₄
Molecular Weight:665.647
Hs Code.:

Synonyms:1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-2,2,2-trifluoroethanol

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Chemical Property of 1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-2,2,2-trifluoroethanol

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Technology Process of 1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-2,2,2-trifluoroethanol

There total 3 articles about 1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-2,2,2-trifluoroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253571-14-0
5-(4-(bis(4-methoxybenzyl)-amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)nicotinaldehyde

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1253577-57-9
1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-2,2,2-trifluoroethanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -15 ℃;
DOI:10.1016/j.bmcl.2014.10.085

Reference yield:

: 886372-63-0
5-fluoro-6-methoxypyridin-3-ylamine

: 1253577-33-1
1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-fluoropyridin-3-yl)-2,2,2-trifluoroethanol

: 1253577-57-9
1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-2,2,2-trifluoroethanol

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran-d8; at -10 ℃; for 0.5h;
DOI:10.1021/jm300846z

Reference yield:

: 1253577-56-8
5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-fluoronicotinaldehyde

: 1253577-57-9
1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-2,2,2-trifluoroethanol

Guidance literature:: Multi-step reaction with 2 steps

1: cesium fluoride / tetrahydrofuran / 3.67 h / 0 - 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran-d8 / 0.5 h / -10 °C

With cesium fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; tetrahydrofuran-d8;
DOI:10.1021/jm300846z