1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-(hydroxy-phenyl-methyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-(hydroxy-phenyl-methyl)-5-isopropyl-1H-pyrimidine-2,4-dione
• CAS No.: 1026714-62-4
• Molecular Formula: C₂₃H₃₆N₂O₅Si
• Molecular Weight: 448.635

Synonyms:1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-(hydroxy-phenyl-methyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Chemical Property of 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-(hydroxy-phenyl-methyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Chemical Property:

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Technology Process of 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-(hydroxy-phenyl-methyl)-5-isopropyl-1H-pyrimidine-2,4-dione

There total 3 articles about 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-(hydroxy-phenyl-methyl)-5-isopropyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-(hydroxy-phenyl-methyl)-5-isopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (1026028-98-7) → 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-(hydroxy-phenyl-methyl)-5-isopropyl-1H-pyrimidine-2,4-dione (1026714-62-4)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; for 1h; Ambient temperature;

DOI:10.1021/jm00015a008

Reference yield:

benzaldehyde (100-52-7) → 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-(hydroxy-phenyl-methyl)-5-isopropyl-1H-pyrimidine-2,4-dione (1026714-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 1 h

2: 35percent H₂O₂, 1 N aq. NaOH / 1 h / Ambient temperature

With sodium hydroxide; dihydrogen peroxide; lithium diisopropyl amide;

DOI:10.1021/jm00015a008

Reference yield:

1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-5-isopropyl-2-thiouracil (137897-85-9) → 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-(hydroxy-phenyl-methyl)-5-isopropyl-1H-pyrimidine-2,4-dione (1026714-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 1 h

2: 35percent H₂O₂, 1 N aq. NaOH / 1 h / Ambient temperature

With sodium hydroxide; dihydrogen peroxide; lithium diisopropyl amide;

DOI:10.1021/jm00015a008

upstream raw materials:

1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-(hydroxy-phenyl-methyl)-5-isopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

benzaldehyde

1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-5-isopropyl-2-thiouracil

Downstream raw materials:

6-(acetoxyphenylmethyl)-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-isopropyluracil

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