methyl 2-amino-3-{[2-(2-benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate

Base Information

Chemical Name:methyl 2-amino-3-{[2-(2-benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate
CAS No.:530112-63-1
Molecular Formula:C₂₉H₂₃N₃O₅
Molecular Weight:493.519
Hs Code.:

Synonyms:methyl 2-amino-3-{[2-(2-benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate

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Chemical Property of methyl 2-amino-3-{[2-(2-benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate

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Technology Process of methyl 2-amino-3-{[2-(2-benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate

There total 5 articles about methyl 2-amino-3-{[2-(2-benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 107582-20-7
2,3-diaminobenzoic acid methyl ester

: 186501-25-7
2-(2-(benzyloxy)phenyl)benzo[d]oxazole-4-carboxylic acid

: 530112-63-1
methyl 2-amino-3-{[2-(2-benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate

Guidance literature:: 2-(2-(benzyloxy)phenyl)benzo[d]oxazole-4-carboxylic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

2,3-diaminobenzoic acid methyl ester; With pyridine; In dichloromethane; at 20 ℃;
DOI:10.1016/S0968-0896(02)00327-9

Reference yield:

: 14389-86-7
2-benzyloxybenzoic acid

: 530112-63-1
methyl 2-amino-3-{[2-(2-benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: carbonyldiimidazole / tetrahydrofuran / 0.08 h / 20 °C

1.2: 87 percent / tetrahydrofuran / 18 h / Heating

2.1: 91 percent / 2 h / 230 °C

3.1: 90 percent / aq. NaOH / tetrahydrofuran / 2 h / 60 °C

4.1: (COCl)2 / CH₂Cl₂; dimethylformamide / 2 h / 20 °C

4.2: 73 percent / pyridine / CH₂Cl₂ / 20 °C

With sodium hydroxide; oxalyl dichloride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00327-9

Reference yield:

: 17672-21-8
2-amino-3-hydroxy-benzoic acid methyl ester

: 530112-63-1
methyl 2-amino-3-{[2-(2-benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: carbonyldiimidazole / tetrahydrofuran / 0.08 h / 20 °C

1.2: 87 percent / tetrahydrofuran / 18 h / Heating

2.1: 91 percent / 2 h / 230 °C

3.1: 90 percent / aq. NaOH / tetrahydrofuran / 2 h / 60 °C

4.1: (COCl)2 / CH₂Cl₂; dimethylformamide / 2 h / 20 °C

4.2: 73 percent / pyridine / CH₂Cl₂ / 20 °C

With sodium hydroxide; oxalyl dichloride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00327-9