1-[[3-(7-chloro-3,4-dihydro-6-nitro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

Base Information

Chemical Name:1-[[3-(7-chloro-3,4-dihydro-6-nitro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine
CAS No.:252232-88-5
Molecular Formula:C₂₂H₂₄ClN₅O₆S
Molecular Weight:521.981
Hs Code.:

Synonyms:1-[[3-(7-chloro-3,4-dihydro-6-nitro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

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Chemical Property of 1-[[3-(7-chloro-3,4-dihydro-6-nitro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

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Technology Process of 1-[[3-(7-chloro-3,4-dihydro-6-nitro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

There total 9 articles about 1-[[3-(7-chloro-3,4-dihydro-6-nitro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 252232-88-5
1-[[3-(7-chloro-3,4-dihydro-6-nitro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

Guidance literature:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 3-(7-chloro-6-nitro-4-oxo-3,4-dihydro-quinazolin-2-yl)-4-propoxy-benzenesulfonyl chloride

: 252232-88-5
1-[[3-(7-chloro-3,4-dihydro-6-nitro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm000081+

Reference yield:

: 40928-13-0
4-chloroisatoic anhydride

: 252232-88-5
1-[[3-(7-chloro-3,4-dihydro-6-nitro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

Guidance literature:: Multi-step reaction with 6 steps

1: 49 percent / conc. H₂SO₄; conc. HNO₃ / 1 h / 0 °C

2: 86 percent / HOAc; NH₄OAc / 3 h / 100 °C

3: 93 percent / pyridine / dimethylformamide / 2.5 h / 80 °C

4: 89 percent / 30percent aq. H₂O₂; NaOH / ethanol / 2 h / Heating

5: chlorosulfonic acid / 5 h / 0 °C

6: Et₃N / CH₂Cl₂; tetrahydrofuran / 2 h / 20 °C

With pyridine; chlorosulfonic acid; sodium hydroxide; sulfuric acid; ammonium acetate; nitric acid; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Nitration / 2: Elimination / 3: Substitution / 4: Cyclization / 5: Substitution / 6: Substitution;
DOI:10.1021/jm000081+