2-(((3S,4E)-5-dimethyl(phenyl)silyl-1-phenyl-4-hexen-3-yl)oxy)-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

Base Information

Chemical Name:2-(((3S,4E)-5-dimethyl(phenyl)silyl-1-phenyl-4-hexen-3-yl)oxy)-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide
CAS No.:1378249-66-1
Molecular Formula:C₂₅H₃₅O₄PSi
Molecular Weight:458.61
Hs Code.:

Synonyms:2-(((3S,4E)-5-dimethyl(phenyl)silyl-1-phenyl-4-hexen-3-yl)oxy)-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

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Chemical Property of 2-(((3S,4E)-5-dimethyl(phenyl)silyl-1-phenyl-4-hexen-3-yl)oxy)-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

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Technology Process of 2-(((3S,4E)-5-dimethyl(phenyl)silyl-1-phenyl-4-hexen-3-yl)oxy)-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

There total 3 articles about 2-(((3S,4E)-5-dimethyl(phenyl)silyl-1-phenyl-4-hexen-3-yl)oxy)-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4090-55-5
2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide

: 1378249-64-9
C₂₀H₂₆OSi

: 1378249-66-1
2-(((3S,4E)-5-dimethyl(phenyl)silyl-1-phenyl-4-hexen-3-yl)oxy)-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

Guidance literature:: C₂₀H₂₆OSi; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/ja302520h

Reference yield:

: 1189125-30-1
(S)-1-phenylhex-4-yn-3-ol

: 1378249-66-1
2-(((3S,4E)-5-dimethyl(phenyl)silyl-1-phenyl-4-hexen-3-yl)oxy)-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylzinc; copper(l) cyanide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diethylzinc; copper(l) cyanide; In tetrahydrofuran;
DOI:10.1021/ja302520h

Reference yield:

: 122124-41-8
1-phenylhex-4-yn-3-one

: 1378249-66-1
2-(((3S,4E)-5-dimethyl(phenyl)silyl-1-phenyl-4-hexen-3-yl)oxy)-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / isopropyl alcohol / 48 h / 20 °C / Inert atmosphere

2.1: diethylzinc; copper(l) cyanide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diethylzinc; copper(l) cyanide; potassium hydroxide; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1021/ja302520h